A NEW APPROACH TO THE DIAGNOSIS OF SEPSIS AND PURULENT-INFLAMMATORY DISEASES

Abstract

INTRODUCTION Sepsis holds the second-highest mortality rate in the world after cardiovascular disease. The problem of sepsis is more than urgent, and in 2017, the World Health Organization (WHO) officially called sepsis a threat to the world and adopted a resolution about this disease. According to the WHO, sepsis is recorded annually in 30 million patients. It leads to 6 million deaths, most of which could be prevented. After all, sepsis is the result of violating the regulation of the response of the macroorganism to infection, manifests with damage to the body’s own tissues and organs and concludes with life-threatening multiple organ failure. In the early stages of sepsis, it can be well treated if it is diagnosed early and the effective treatment and monitoring of patients conditions are timely. However, currently the solution of this problem is difficult due to the lack of effective methods of early diagnosis and pathogenetic treatment of this disease 1 . The 70th WHO Assembly adopted the resolution about the need of developing the clinical guidelines for the prevention of sepsis, its diagnosis and treatment. This issue is to be re-examined by the 73rd WHO Assembly. Therefore, the relevance of this problem is currently very high, but not yet solved, despite the large number of scientific research. Sepsis during pregnancy and postpartum period remains the leading cause of maternal morbidity and mortality worldwide. Its occurrence is characteristic of both developing and highly developed countries. It should be noted that there are significant difficulties in the diagnosis of obstetric sepsis compared with the diagnosis of sepsis in the general population. First of all, the onset of postpartum purulent-inflammatory diseases (PPPID) is now often accompanied with an atypical aberrant course, characterized by discrepancy between nonspecific common manifestations and the severity of the local pathological process. In addition, during pregnancy, there are characteristic physiological changes that negate the informativeness of