Studies on the Compatibility between Lincomycin and Kitassamycin in the Control of Necrotic Enteritis in Broiler Chickens

Abstract

A total of 75 one-day old broiler chickens were used in this study for investigate compatibility between Lincomycin and Kitasamycin for treating clostridium perfringens infection and its effects in hematobiochemical parameters. At day 15 of age broilers were divided into 5 equal groups. Chicks in groups (2, 3, 4 and 5) were infected with clostridium perfringens type C, 1 st group non-infected, non-treated (-ve control), 2 nd group-infected non-treated(+ve control), 3 rd group infected lincomycin treated for 5 days, 4 th group infected kitasamycin treated for 5 days and 5 th group infected treated with both drugs together by same dose and period. At 1 st day post treatment 2 blood sample was taken from all birds for hematobiochemical study. Infected broilers showed clinical signs as loss of appetite ruffled feathers, depression, loss of appetite, diarrhea, dehydration, polydipsia, ema -ciation, significant reduction in body weight gain total protein, albumin, catalase and superoxide dismutase beside significant increase in mortality rate, feed conversion rate, leukocytic count, heterophile, lymphocyte, monocyte, eosinophile, basophile, phagocytosis and index, liver enzyme (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase) uric acid, creatinine, malanodialdhyde coupled with insignificant increase in total globulin, alpha, beta and gamma globulin beside insig nificant decrease in total lipids, triglycerides and cholesterol. Necrotic entritits induced many pathological leion in liver, kidney and intestine Treatment infected broilers using lincomycin and kitassmycin lead to improved in hematobiochemical parameter and reduction in clostridium perfringens counts in faeces and bacterial reiolation but infected broilers treated with both drugs together showed superior improvement in hematobiochemical parameter. It could be concluded that Combination of lincomycin and kitassmycin is effective in treatment necrotic entritis than each alone.