In vivo animal experimental research of magnetic nanoparticles influence on pulse wave

2010 3rd International Conference on Biomedical Engineering and Informatics Pub Date : 2010-11-18 DOI:10.1109/BMEI.2010.5639519

Yupeng Yao, Shouliang Qi, Jingshu Zhang, Bowen Song, Cong Feng, Lisheng Xu

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Abstract

In vivo animal experimental research is performed to study the influence of magnetic nanoparticles on the pulse wave. An interventional pulse wave transducer is connected to the rabbit's blood circulation through the ingenious two-end carotid intubations, so that the pulse wave with low noise could be acquired. The data obtained before and after the injection of the magnetic nanoparticles, which have the diameter of 20 nm, is processed and compared in both time and frequency domain. It is found that after injection, pulse wave height is about 10 mmHg higher, and its interval is about 4.55% longer. While the fluctuation of respiration is much more gently, the acuity of pulse wave fluctuation increases. It is likely to say that injection has elevated the blood pressure and brought down the excitation of the rabbits. According to the relationship between the blood pressure and the blood viscosity of human body, the injection of nanoparticles has increased the blood viscosity of the rabbit. The results are very instructive for the study of in vivo transport of magnetic nanoparticles, which is the base of targeted drug delivery, hyperthermia and embolism therapy using nanoparticles.

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磁性纳米颗粒对脉冲波影响的动物体内实验研究

通过动物体内实验研究磁性纳米颗粒对脉冲波的影响。通过巧妙的颈动脉两端插管，将介入性脉搏波换能器连接到兔子的血液循环中，获得低噪声的脉搏波。对直径为20 nm的磁性纳米颗粒注射前后的数据进行时域和频域处理和比较。研究发现，注入后脉冲波高提高约10 mmHg，间隔时间延长约4.55%。呼吸的波动较平缓，但脉搏波动的敏锐度增加。可以说，注射使家兔血压升高，兴奋程度降低。根据人体血压与血液黏度的关系，注射纳米颗粒增加了家兔的血液黏度。研究结果对研究磁性纳米颗粒的体内转运具有重要的指导意义，为纳米颗粒靶向给药、热疗和栓塞治疗奠定了基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2010 3rd International Conference on Biomedical Engineering and Informatics

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