A Review on Pyridazinone Compounds ABT-963 as Selective CyclooxygenaseInhibitor

Abstract

Vicinally disubstituted pyridazinones act as potent and selective COX-2 inhibitors. Compound, ABT-963, (2-(3,4-difluoro-phenyl)-4-(3-hydroxy-3-methyl-butoxy)-5-(4-methanesulfonyl-phenyl)-2H-pyridazin-3-one) has an excellent selectivity (ratio of 276, COX-2/COX-1), improved aqueous solubility compared with celecoxib and rofecoxib, high oral anti-inflammatory potency and gastric safety in the animals. After oral administration, ABT-963 reduced prostaglandin (PG) E2 production and reduced the edema. ABT-963 dose dependently reduced nociception. ABT-963 significantly reduced bone loss and soft tissue destruction. ABT-963 is a highly selective COX-2 inhibitor that may be used in the treatment of the pain and inflammation associated with arthritis.