Relationship between Locus of Control Belief and IL-6 in Breast Cancer Patients

Journal of Cancer and Biomedical Research Pub Date : 2018-06-01 DOI:10.21608/jcbr.2019.34733

A. El-Amir, M. Salem, Noha Sabry, Eman M. El-Baiomy, N. El-Mashad

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引用次数: 1

Abstract

Recent studies indicated to the immune disturbances in cancer patients in comparison with healthy individuals. Several studies suggested that individuals with external locus of control (E-LOC) have more symptoms of depression. Other studies indicated to the effective role of psychological status on the immune system. The association between E-LOC and immunity in cancer patients it is not clear. Study the relation between Rotter internal-external locus of control (I-E LOC) and God health locus of control (GHLC) and interleukin-6 (IL-6) in breast cancer patients. The study included hundred breast cancer patients and fifty healthy controls. Patients and participators responded to I-E LOC and GHLC questionnaires. Peripheral blood samples were collected to measure gene expression of IL6 by using real time PCR. Breast cancer patients showed higher GHLC which was associated with higher level of IL-6 as compared to control subjects. By contrast, a significant inverse correlation between GHLC and IL-6 was found. However, there was no relationship between I-E LOC and IL-6. The results suggest no significant effect of LOC belief according to life on immune response against cancer, but high GHLC belief correlate with decreased IL-6. Further studies on the relations between other types of LOC and immune response in breast cancer is recommended. Article history:

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乳腺癌患者控制位点信念与IL-6的关系

近年来的研究表明，与健康个体相比，癌症患者的免疫功能紊乱更明显。一些研究表明，具有外部控制点(E-LOC)的个体有更多的抑郁症状。其他研究表明心理状态对免疫系统的有效作用。E-LOC与癌症患者免疫之间的关系尚不清楚。探讨乳腺癌患者Rotter内外控制位点(I-E LOC)与健康控制位点(GHLC)、白细胞介素-6 (IL-6)的关系。该研究包括100名乳腺癌患者和50名健康对照者。患者和参与者回答了I-E LOC和GHLC问卷。采集外周血标本，采用实时荧光定量PCR检测il - 6基因表达。与对照组相比，乳腺癌患者的GHLC更高，这与更高水平的IL-6有关。相反，GHLC与IL-6呈显著负相关。然而，I-E LOC与IL-6之间没有关系。结果表明，按生命计数的LOC信念对肿瘤免疫应答无显著影响，但高GHLC信念与IL-6的降低相关。建议进一步研究其他类型LOC与乳腺癌免疫应答的关系。文章历史:

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Cancer and Biomedical Research

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