Effectiveness of isoprothiolane in preventing fatty liver in dairy cows.

The Open Veterinary Science Journal Pub Date : 2013-02-22 DOI:10.2174/1874318801307010001

J. Minaguchi, Michisaburoh Miura, S. Oikawa, Fumi Handa, Takuya Haraguchi, Kazuyoshi Miyamoto-Ohno, Yuta Ito, Y. Hosaka, H. Ueda, K. Takehana

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Abstract

In this study, we evaluated the effectiveness of isoprothiolane in preventing fatty liver in dairy cows. Eight pregnant Holstein cows with high body condition scores were studied. Four cows were administered isoprothiolane via feed at 10 g/day/head from 21 days before delivery (treated group), while the remaining four cows received no treatment (non-treated group). Liver samples from both groups were obtained 21 days before delivery and 2 days following delivery. No accumulation of lipid droplets in hepatocytes was observed in any cows prior to delivery. Following delivery, the accumulation of lipid droplets in hepatocytes was significantly reduced in the treated group compared to the non-treated group. The number of mitochondria per unit area was also significantly smaller in the treated group than in the non-treated group. Blood and biochemical test results from cows in the treated group showed an increase in mGOT levels and stable intrahepatic ATP production. These results suggest that isoprothiolane treatment intensified beta-oxidation in liver mitochondria, thereby activating the TCA cycle and maintaining intrahepatic ATP production.

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异丙硫烷预防奶牛脂肪肝的效果。

在本研究中，我们评估了异丙硫烷预防奶牛脂肪肝的有效性。以8头体况评分较高的妊娠荷斯坦奶牛为研究对象。从分娩前21 d开始，4头奶牛以10 g/d /头的剂量通过饲料添加异丙硫烷(处理组)，其余4头奶牛不添加任何处理(未处理组)。两组分别于分娩前21天和分娩后2天采集肝脏标本。在分娩前，没有观察到任何奶牛肝细胞中脂滴的积累。分娩后，与未治疗组相比，治疗组肝细胞中脂滴的积累显著减少。治疗组每单位面积的线粒体数量也明显少于未治疗组。处理组奶牛的血液和生化测试结果显示，mGOT水平升高，肝内ATP产量稳定。这些结果表明，异丙硫烷处理增强了肝脏线粒体的β -氧化，从而激活TCA循环并维持肝内ATP的产生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Open Veterinary Science Journal

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