A geriatric study of longevity via big data analytics of metabolism and medical conditions using GH-Method: math-physical medicine

Gerald C. Hsu
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引用次数: 3

Abstract

In the beginning, from 2010 to 2013, he self-studied internal medicine and food nutrition. He specifically focused on six chronic diseases, i.e. obesity, diabetes, hypertension, hyperlipidemia, cardiovascular diseases (CVD) & stroke, and chronic kidney disease (CKD). In 2014, he allotted the entire year to develop a complex mathematical metabolism model which includes 4 output categories (weight, glucose, blood pressure, lipids) and 6 input categories (food, water, exercise, sleep, stress, life routine regularity). There are about 500 detailed elements included in these 10 categories. Since using a theoretical approach to deal with a dataset of 10 categories with 500 elements, the problem of identifying and solving all possible interactive relationships among them would be an immense task. This task would include complicated calculations of 500 ! steps. This kind of approach is a huge undertaking without any obvious benefit; therefore, he adopted an approach of applying mathematical concept that is topology. In addition, he applied a practical engineering modeling technique such as finite element method to seek a quicker but rather accurate solution for this complicated biomedical system. At the end, he was able to develop a mathematical metabolism model embedded in a specially designed application software on the iPhone (“eclaireMD system”) for his daily use in order to maintain his health status and also serve as a useful research tool for his ongoing various medical research projects. During the development process, he has defined two more new variables, metabolism index (MI) and general health status unit (GHSU), where GHSU is the 90-days moving average MI that is similar to HbA1C’s 90-days moving average glucoses. The results of this dynamic model can be expressed through these two newly defined variables, MI and GHSU, to describe a person’s overall health status and shortcomings in any specific area at any moment in time.
利用GH-Method:数学-物理医学,通过对新陈代谢和医疗状况的大数据分析,对老年人的长寿进行研究
从2010年到2013年,他自学了内科和食品营养学。他特别关注六种慢性疾病,即肥胖、糖尿病、高血压、高脂血症、心血管疾病(CVD)和中风、慢性肾脏疾病(CKD)。2014年,他花了一整年的时间建立了一个复杂的数学代谢模型,该模型包括4个输出类别(体重、血糖、血压、血脂)和6个输入类别(食物、水、运动、睡眠、压力、生活规律)。在这10个类别中包含了大约500个详细的元素。由于使用理论方法来处理包含10个类别和500个元素的数据集,因此识别和解决它们之间所有可能的交互关系的问题将是一项巨大的任务。这项任务将包括500的复杂计算!步骤。这种方法是一项巨大的工程,没有任何明显的好处;因此,他采用了一种应用数学概念的方法,即拓扑学。此外,他还运用了有限元法等实用的工程建模技术,为这一复杂的生物医学系统寻求一种更快但更准确的解决方案。最后,他开发了一个数学代谢模型,嵌入在iPhone上专门设计的应用软件(“eclaireMD系统”)中,供他日常使用,以保持他的健康状态,并为他正在进行的各种医学研究项目提供有用的研究工具。在开发过程中,他又定义了两个新的变量,代谢指数(MI)和一般健康状态单位(GHSU),其中GHSU是90天移动平均MI,类似于HbA1C的90天移动平均血糖。该动态模型的结果可以通过新定义的两个变量MI和GHSU来表达,以描述一个人在任何特定区域、任何时刻的整体健康状况和不足。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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