Development of a Continuous Blood Pressure Monitoring System based on Pulse Transit Time and Hemodynamic Covariates

Yiming Zhang, Congcong Zhou, Zhongyi Huang, Xuesong Ye
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引用次数: 5

Abstract

There were many studies showing the relation between pulse transit time (PTT) and blood pressure (BP). Besides, hemodynamic covariates may also contribute to BP values. Our previous study has proposed a BP model based on PTT, HR, stiffness index (SIx) and descent time (DT), which has been validated on the Multiparameter Intelligent Monitoring for Intensive Care (MIMIC) database. In this article, we present a prototype cuff-less monitoring device for non-invasive estimation of BP, which can obtain both electrocardiogram (ECG) and finger plethysmograph (PPG) signals synchronously. The model proposed above has been validated by using ECG and PPG records from 22 healthy subjects with no cardiovascular disease and hypertension, and the error of BP estimation was 0.002±8.544 mmHg for SBP, 0.005±6.690 mmHg for DBP. The reliability of this method in long-term BP monitoring was further verified by studying the data of one individual for 28 days, while the error was 5.204±5.462 mmHg for SBP, 2.714±4.756 mmHg for DBP without calibration. The results show that the model could estimate the BP value within the acceptable error range based on this study, which is extremely close to AAMI's standard (5±8mmHg) and consistent with the cuff-method. The proposed ultra-low power, wearable, time-synchronized prototype monitoring device with an embedded hemodynamic covariate model, can measure SBP and DBP values accurately, which is expected to estimate continuous blood pressure better.
基于脉冲传递时间和血流动力学协变量的连续血压监测系统的研制
许多研究显示脉搏传递时间(PTT)与血压(BP)之间的关系。此外,血流动力学协变量也可能影响血压值。我们之前的研究提出了一个基于PTT、HR、刚度指数(SIx)和下降时间(DT)的BP模型,并在多参数重症监护智能监测(MIMIC)数据库上进行了验证。在本文中,我们提出了一种原型的无袖带监测装置,用于无创血压估计,它可以同步获得心电图(ECG)和手指体积描记仪(PPG)信号。通过22名无心血管疾病和高血压的健康受试者的心电图和PPG记录验证了上述模型,收缩压估计误差为0.002±8.544 mmHg,舒张压估计误差为0.005±6.690 mmHg。通过对个体28天的数据研究,进一步验证了该方法在长期血压监测中的可靠性,无标定时收缩压误差为5.204±5.462 mmHg,舒张压误差为2.714±4.756 mmHg。结果表明,基于本研究的模型能在可接受的误差范围内估计出BP值,与AAMI的标准(5±8mmHg)极为接近,与卡夫法一致。所提出的超低功耗、可穿戴、时间同步的原型监测装置具有嵌入式血流动力学协变量模型,可以准确测量收缩压和舒张压值,有望更好地估计持续血压。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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