Any Target Value of LDL-cholesterol before Elective PCI? A study at NICVD on Association of LDL-Cholesterol levels with Myocardial Injury during Elective PCI

Bangladesh Heart Journal Pub Date : 2023-07-08 DOI:10.3329/bhj.v38i1.67221

M. Hasan, S. Hashem, Mohsin Ahmed, M. Haque, J. Jahan, M. Kabir, Md Imam Hosen, Tausif Amim Shadly

{"title":"Any Target Value of LDL-cholesterol before Elective PCI? A study at NICVD on Association of LDL-Cholesterol levels with Myocardial Injury during Elective PCI","authors":"M. Hasan, S. Hashem, Mohsin Ahmed, M. Haque, J. Jahan, M. Kabir, Md Imam Hosen, Tausif Amim Shadly","doi":"10.3329/bhj.v38i1.67221","DOIUrl":null,"url":null,"abstract":"Background: Raised LDL cholesterol has already been established as a strong risk factor the for pathogenesis of atherosclerotic plaque leading to coronary heart disease. During PCI procedure, many patients develop peri-procedural myocardial injury due to mainly atherosclerotic plaque disruption, side branch occlusion and distal small vessel embolization which subsequently affects the mortality and morbidity of patients. \nObjectives: To find out the association of preprocedural LDL cholesterol levels with myocardial injury in elective PCI patients. \nMethods: This Cross-sectional observational study was conducted at National Institute of Cardiovascular Diseases (NICVD), Dhaka from July 2020 to June 2021. The sample size was 170. LDL cholesterol and troponin-I were measured before the procedure and troponin I was measured 6 hours after PCI procedure. On the basis of pre-procedural cholesterol level, the study population were categorized into two groups: Group I: patients with normal LDL-C level (£70mg/dl) and Group II :patients with raised LDL-C (>70mg/dl). \nResults: Total 54(31.8%) patients developed peri-procedural myocardial injury, among them 15(19.7%) were in normal LDL-C group and 39(41.5%) were in raised LDL-C group. Elevation of troponin I after PCI was higher in group II than group I patients with statistically significant difference (p<0.001). Multivariate logistic regression analyses showed that raised LDL-C was an independent predictor of PMI (OR 4.71; 95% CI, 2.072- 10.658; p<0.001). There was positive correlation found between pre-procedural LDL-C and myocardial injury (r=0.44, p<0.001) by Pearson’s correlation coefficient test. \nConclusion: Pre-procedural raised LDL-C level was positively and independently associated with myocardial injury after elective percutaneous coronary intervention (PCI). \nBangladesh Heart Journal 2023; 38(1): 70-80","PeriodicalId":247590,"journal":{"name":"Bangladesh Heart Journal","volume":"284 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bangladesh Heart Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3329/bhj.v38i1.67221","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Raised LDL cholesterol has already been established as a strong risk factor the for pathogenesis of atherosclerotic plaque leading to coronary heart disease. During PCI procedure, many patients develop peri-procedural myocardial injury due to mainly atherosclerotic plaque disruption, side branch occlusion and distal small vessel embolization which subsequently affects the mortality and morbidity of patients. Objectives: To find out the association of preprocedural LDL cholesterol levels with myocardial injury in elective PCI patients. Methods: This Cross-sectional observational study was conducted at National Institute of Cardiovascular Diseases (NICVD), Dhaka from July 2020 to June 2021. The sample size was 170. LDL cholesterol and troponin-I were measured before the procedure and troponin I was measured 6 hours after PCI procedure. On the basis of pre-procedural cholesterol level, the study population were categorized into two groups: Group I: patients with normal LDL-C level (£70mg/dl) and Group II :patients with raised LDL-C (>70mg/dl). Results: Total 54(31.8%) patients developed peri-procedural myocardial injury, among them 15(19.7%) were in normal LDL-C group and 39(41.5%) were in raised LDL-C group. Elevation of troponin I after PCI was higher in group II than group I patients with statistically significant difference (p<0.001). Multivariate logistic regression analyses showed that raised LDL-C was an independent predictor of PMI (OR 4.71; 95% CI, 2.072- 10.658; p<0.001). There was positive correlation found between pre-procedural LDL-C and myocardial injury (r=0.44, p<0.001) by Pearson’s correlation coefficient test. Conclusion: Pre-procedural raised LDL-C level was positively and independently associated with myocardial injury after elective percutaneous coronary intervention (PCI). Bangladesh Heart Journal 2023; 38(1): 70-80

查看原文本刊更多论文

选择性PCI术前ldl -胆固醇有目标值吗?NICVD择期PCI期间ldl -胆固醇水平与心肌损伤的相关性研究

背景:低密度脂蛋白胆固醇升高已被确定为导致冠心病的动脉粥样硬化斑块发病的一个重要危险因素。在PCI手术过程中，许多患者发生术中心肌损伤，主要是由于动脉粥样硬化斑块破裂、侧支闭塞和远端小血管栓塞，从而影响患者的死亡率和发病率。目的:探讨择期PCI患者术前LDL胆固醇水平与心肌损伤的关系。方法:本横断面观察性研究于2020年7月至2021年6月在达卡国立心血管疾病研究所(NICVD)进行。样本量为170人。术前测定LDL胆固醇和肌钙蛋白I, PCI术后6小时测定肌钙蛋白I。根据术前胆固醇水平，将研究人群分为两组:I组:LDL-C水平正常(£70mg/dl)的患者;II组:LDL-C升高(>70mg/dl)的患者。结果:54例(31.8%)患者发生术中心肌损伤，其中LDL-C正常组15例(19.7%)，LDL-C升高组39例(41.5%)。PCI术后II组肌钙蛋白I升高高于I组，差异有统计学意义(p<0.001)。多因素logistic回归分析显示LDL-C升高是PMI的独立预测因子(OR 4.71;95% ci, 2.072- 10.658;p < 0.001)。经Pearson相关系数检验，术前LDL-C与心肌损伤呈正相关(r=0.44, p<0.001)。结论:术前LDL-C水平升高与择期经皮冠状动脉介入治疗(PCI)后心肌损伤呈正相关。孟加拉国心脏杂志2023;38 (1): 70 - 80

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Bangladesh Heart Journal

自引率

0.00%

发文量