The Effect of Probiotics on Short Chain Fatty Acid Levels in Colorectal Cancer Patients Who Undergoing Chemotherapy at Dr. Mohammad Hoesin General Palembang Hospital

Fifi Yuniarti, M. Syahrir, Z. Ali, Y. D. Andayani, Norman Djamaluddin
{"title":"The Effect of Probiotics on Short Chain Fatty Acid Levels in Colorectal Cancer Patients Who Undergoing Chemotherapy at Dr. Mohammad Hoesin General Palembang Hospital","authors":"Fifi Yuniarti, M. Syahrir, Z. Ali, Y. D. Andayani, Norman Djamaluddin","doi":"10.32996/jmhs.2022.3.4.10","DOIUrl":null,"url":null,"abstract":"Chemotherapy is the modality of colon cancer therapy that can reduce SCFA levels in the intestine. Probiotics are currently known to have a role in the pathogenesis of colon cancer and adjunct therapy for colon cancer patients. This study aims to examine the effect of probiotics on SCFA levels in faeces in colorectal cancer patients undergoing chemotherapy at RSMH Palembang; A randomized controlled trial in Hematology Oncology Policlinic between September 2021 and September 2022. The total number of subjects was 44, and then SCFA stool levels were examined at the study's beginning and end; Then, the analysis was carried out. About 37 subjects (19 probiotic group and 18 placebo groups) were analyzed, mean age was 45,62 ± 8,98 years. After intervention, the mean change of SCFA were 0.5786 ±3.887 mg/ml in probiotic group VS -2, 22 ±2.045 mg/mL (p-value 0.001). Probiotics have a significant effect on increasing SCFA levels in colorectal patients who were undergoing chemotherapy at Dr. Mohammad Hoesin General Palembang Hospital.","PeriodicalId":162243,"journal":{"name":"Journal of Medical and Health Studies","volume":"42 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Medical and Health Studies","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32996/jmhs.2022.3.4.10","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Chemotherapy is the modality of colon cancer therapy that can reduce SCFA levels in the intestine. Probiotics are currently known to have a role in the pathogenesis of colon cancer and adjunct therapy for colon cancer patients. This study aims to examine the effect of probiotics on SCFA levels in faeces in colorectal cancer patients undergoing chemotherapy at RSMH Palembang; A randomized controlled trial in Hematology Oncology Policlinic between September 2021 and September 2022. The total number of subjects was 44, and then SCFA stool levels were examined at the study's beginning and end; Then, the analysis was carried out. About 37 subjects (19 probiotic group and 18 placebo groups) were analyzed, mean age was 45,62 ± 8,98 years. After intervention, the mean change of SCFA were 0.5786 ±3.887 mg/ml in probiotic group VS -2, 22 ±2.045 mg/mL (p-value 0.001). Probiotics have a significant effect on increasing SCFA levels in colorectal patients who were undergoing chemotherapy at Dr. Mohammad Hoesin General Palembang Hospital.
益生菌对在Mohammad Hoesin博士综合医院接受化疗的结直肠癌患者短链脂肪酸水平的影响
化疗是结肠癌治疗的一种方式,可以降低肠道内的SCFA水平。目前已知益生菌在结肠癌的发病机制和结肠癌患者的辅助治疗中起作用。本研究旨在研究益生菌对巨港RSMH化疗的结直肠癌患者粪便中SCFA水平的影响;2021年9月至2022年9月在血液学肿瘤学临床进行的一项随机对照试验。受试者总数为44人,然后在研究开始和结束时检测SCFA粪便水平;然后,进行分析。共分析37例受试者(益生菌组19例,安慰剂组18例),平均年龄为45、62±8、98岁。干预后,益生菌组SCFA的平均变化为0.5786±3.887 mg/ml VS - 2,22±2.045 mg/ml (p值0.001)。益生菌对在Mohammad Hoesin博士综合巨港医院接受化疗的结直肠癌患者的SCFA水平有显著影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信