The Effect of Probiotics on Short Chain Fatty Acid Levels in Colorectal Cancer Patients Who Undergoing Chemotherapy at Dr. Mohammad Hoesin General Palembang Hospital

Journal of Medical and Health Studies Pub Date : 2022-10-27 DOI:10.32996/jmhs.2022.3.4.10

Fifi Yuniarti, M. Syahrir, Z. Ali, Y. D. Andayani, Norman Djamaluddin

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Abstract

Chemotherapy is the modality of colon cancer therapy that can reduce SCFA levels in the intestine. Probiotics are currently known to have a role in the pathogenesis of colon cancer and adjunct therapy for colon cancer patients. This study aims to examine the effect of probiotics on SCFA levels in faeces in colorectal cancer patients undergoing chemotherapy at RSMH Palembang; A randomized controlled trial in Hematology Oncology Policlinic between September 2021 and September 2022. The total number of subjects was 44, and then SCFA stool levels were examined at the study's beginning and end; Then, the analysis was carried out. About 37 subjects (19 probiotic group and 18 placebo groups) were analyzed, mean age was 45,62 ± 8,98 years. After intervention, the mean change of SCFA were 0.5786 ±3.887 mg/ml in probiotic group VS -2, 22 ±2.045 mg/mL (p-value 0.001). Probiotics have a significant effect on increasing SCFA levels in colorectal patients who were undergoing chemotherapy at Dr. Mohammad Hoesin General Palembang Hospital.

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益生菌对在Mohammad Hoesin博士综合医院接受化疗的结直肠癌患者短链脂肪酸水平的影响

化疗是结肠癌治疗的一种方式，可以降低肠道内的SCFA水平。目前已知益生菌在结肠癌的发病机制和结肠癌患者的辅助治疗中起作用。本研究旨在研究益生菌对巨港RSMH化疗的结直肠癌患者粪便中SCFA水平的影响;2021年9月至2022年9月在血液学肿瘤学临床进行的一项随机对照试验。受试者总数为44人，然后在研究开始和结束时检测SCFA粪便水平;然后，进行分析。共分析37例受试者(益生菌组19例，安慰剂组18例)，平均年龄为45、62±8、98岁。干预后，益生菌组SCFA的平均变化为0.5786±3.887 mg/ml VS - 2,22±2.045 mg/ml (p值0.001)。益生菌对在Mohammad Hoesin博士综合巨港医院接受化疗的结直肠癌患者的SCFA水平有显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Medical and Health Studies

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