Symptomatic Nephroptosis (SN) Causes the Loin Pain and Haematuria Syndrome (LPHS)

Abstract

The objective of this letter is to report recent advances on the diagnosis and therapy of the loin pain hematuria syndrome (LPHS). The patho-aetiological link of LPHS with symptomatic nephroptosis (SN) is a novel discovery of the 21st century that was first preliminary reported in 2002 [1]. The link was confirmed in 2016 in an article that précised the exact pathoaetiology of LPHS; ischemic nephritis and sympathetic neuropathy of SN. It also advanced a 100% curative therapy for LPHS namely; the renal sympathetic denervation and nephropexy (RSD&N) surgery [2]. Symptomatic nephroptosis has been known for centuries [3] but was disparaged [4] >70 years ago and omitted from all textbooks. Hence it is a forgotten disease. The loin pain hematuria syndrome was first reported in 1967 [5] and has remained without any effective therapy till now [6-8].