THE EFFECT OF THE AC-D-MPRG PEPTIDE BASED ON THE C-TERMINAL FRAGMENT OF ARGININE-VASOPRESSIN(6-9) ON THE CHARACTER OF RATS OF DIFFERENT AGES

Abstract

RuIn this work, it was found that Ac-D-MPRG, a tetrapeptide synthesized on the basis of the C-terminal fragment of arginine-vasopressin(6-9), upon chronic neonatal administration, a ects anxiety and exploratory behavior in rats of three age groups. The most signi cant effect of the peptide was manifested under more stressful conditions. The rats of the experimental group showed less anxiety. They did less grooming in the Elevated Plus Maze test and increased time in light in the Light-Dark Chamber test. Motor activity changed from passive holding in the prepubertal period to active avoidance in puberty and adulthood. Based on the data obtained, we conclude that the effects of the peptide are manifested only when exposed to a biologically signi cant stimulus.