Study of platelet count and platelet volume indices in the spectrum of coronary artery diseases and its clinicopathological correlation

Abstract

Introduction: Larger platelets are enzymatically and metabolically more active and have higher thrombotic ability compared to the smaller one. The mean platelet volume (MPV) and other platelet volume indices quantification have been appreciated as biomarker of cardiovascular disease. Aims and Objectives: To determine the platelet count, the various platelet volume indices and and to evaluate any statistical difference between these values among the patients of acute myocardial infarction (AMI), unstable and stable angina in age and sex matched control group. Materials and Methods: 35 cases of AMI/unstable angina, 35 cases of stable angina were compared with 35 non cardiac patients with respect to platelet counts, MPV, PDW and PCT. All the parameters were measured as per standard protocol. Patients with bleeding disorder, thrombocytopenia, liver and kidney disease were excluded. Result and Analysis: In our study MPV and mean PDW were significantly higher in acute myocardial infarction/unstable angina patients than stable angina (P < 0.05). Statistically significant higher PDW and MPV were also observed in AMI/UA patients than control subjects (P < 0.05). Conclusion: Measurement of platelet count and platelet volume indices may be of some benefit in detecting those patients at higher risk of an acute coronary syndrome.