Investigation of the Association between rs2296283 and rs7337610 Polymorphisms of FLT-1 Gene with Behcet’s Disease in the Population of Tehran-Iran

Abstract

Background: Behcet’s Disease (BD) is a rare autoimmune disease with undetermined etiology. In this study, the association of rs2296283 and rs7337610 polymorphisms of FLT-1 gene with the possibility for BD was investigated in Tehran population. Methods: In this case-control study, 100 samples (50 patients with BD and 50 healthy individuals with no background of disease) were examined. PCR-RFLP procedure was performed to determine the rs2296283 and rs7337610 polymorphisms using the HaeIII and MseI enzymes, respectively. SNPStats software was used for the analysis of association study. Results: The frequencies of CC, CT, and TT genotypes for rs2296283 polymorphism were 26, 35, and 39% in patients, and 32, 34, and 34% in healthy population, respectively (p>0.05). The frequency of TT, CT and CC genotypes for FLT-1 rs7337610 polymorphism in patients with BD was 18%, 31%, 51% and in healthy or control groups was 14%, 36% and 50%, respectively (p>0.05). Conclusion: No significant relationship was observed between rs2296283 and rs7337610 polymorphisms and the BD. Study on a greater number of samples is proposed.