Potential Events of Drug Interactions among Elderly Hypertensive Patients in Surakarta Hospital

Abstract

: The use of antihypertensive drugs cannot be separated from the incidence of drug interactions. A study in 2017, showed that of 80 geriatric patients with hypertensive heart disease (HHD), 240 cases of potential drug interactions were found at Moewardi Hospital. This study aims to determine potential incidence of drug interactions in elderly hypertensive patients at Surakarta Hospital. This is an observational study using a cross-sectional method with retrospective data collection of patients in 2018 who were treated at Surakarta Hospital. The inclusion criteria were elderly patients more than 60 years, diagnosed with hypertension with or without comorbidities and receiving antihypertensive and non-antihypertensive drugs. Potential drug interactions were studied theoretically using Medscape.com. The data obtained were analyzed descriptively with cross-tabulation. The results of study were 86 patients who met the inclusion criteria. The theoretical potential for drug interactions was found in 98 cases from 505 cases. Pharmacodynamic drug interactions were most common in the use of bisoprolol with aspirin and furosemide with aspirin in 10 and 8 cases, respectively. The interaction between Valsartan and Atorvastatin as many as 6 cases with the type of pharmacokinetic interaction. It can be concluded that there are more pharmacodynamics than pharmacokinetic drug interactions.