The Effect of Tamarind Leaves (tamarindus indica linn) and Acarbose on Body Weight in Rats Type 2 Diabetes Mellitus Model

Abstract

— Diabetes mellitus is a disease that causes an increase in blood glucose so that glucose in the calories is difficult to enter the cell and glycogenolysis process occurs then continues to the process of gluconeogenesis so that the body lacks energy and unloads food reserves in the muscles and adipose which results in the occurrence of weight loss in people with T2DM. Antioxidants are needed, namely tamarind leaves to help glucose enter cells. This study used 30 wistar rats that were 8 weeks old and weighed 150-200 g. Rats were induced with STZ as much as 45 mg / kg, then Na as much as 110 mg / kg. In this study, rats were grouped into 5 groups namely, KN groups which were DMT2 rats without treatment, KP group who were DMT2 rats given acarbose drugs by 1.8 mg / KgBB / day and Group P1, P3, P3 were given leaf treatment tamarind with a dose of 28.56, and 112 mg / 200gr / day for 14 days. All data were collected and analyzed using ANOVA and LSD post hoc with p value <0.05. In fasting blood glucose, the mean of all groups of rats was 264.83 ± 1.47 and the mean of body weight of rats after STZ induction was 180 ± 3.84. After 7 days of treatment, the body weight of rats in the treatment of KP (184.17 ± 3.18), P1 (182.50 ± 6.15), P2 (182.17 ± 5.77), and P3 (189.67) ± 2.65) increased significantly, whereas in the KN group (173.67 ± 4.59) weight loss occurred in the DMT2 model rats. Giving extract of tamarind leaves in P3 is better than KP which is an acarbose drug. Provision of tamarind leaves for 7 days, in the treatment group P3 increased body weight of rats and treatments P1 and P2 increased body weight the same as the treatment group KP (acarbose).