Arsenic: A Cause of Cardiometabolic Syndromes

Abstract

Objective: The objective of the study is to identify major pathological biomarkers and their possible mechanisms in arsenic-induced cardiometabolic syndrome. Methodology: The present review summarizes the data and literature taken from previously done studies from Research Gate, Science Direct, PubMed, PubMed Central, Medline, and some other scientific databases emphasizing the role of arsenic in cardiometabolic syndrome. The results obtained through this database were assembled, composed, critically elucidated and presented in explanatory and tabular form. Results: The major pathological target of arsenic is antioxidant defense system and increase in Reactive Oxygen Species reduces the Nitric oxide production, reduction in vascular permeability, increases adhesion and production of inflammatory mediators (IL-6, TNF-á,), TCs, TGs, LDL-C, lipid peroxidation, â-cells dysfunction. The persistent accumulation and generation of these pathological biomarkers in blood vessels can induce hyperlipidemias, dyslipidemias, atherosclerosis, hypertension and diabetes. Conclusion: There is a need to propose natural antioxidant with minimum side effects in the treatment of CMTs.