Mapping Aging Biomarkers and Pathways Using Proteomics

Abstract

: Aging is the leading factor in many diseases. During aging, a lot of proteins and pathways are dramatically changed, which may serve as potential aging biomarkers and targets for anti-aging drug development. In this review, we summarize the current progress in aging-related biomarkers and pathways that have been identified by proteomics. We find that many proteins in metabolism pathways are involved in aging process, which have a positive- or a negative-correlation. Changes in many have strong relationship with aging, including mTOR pathway, pro-inflammatory pathway, insulin/insulin-like signaling pathway, mitochondrial function pathway.