Frequency of Isolation and Antibiotic Resistance Patterns of Bacterial Isolates from Wound Infections, National Cancer Institute, Wad-Medani, Sudan, 2021

Omer Abu Elhasan Mohammed, Abbakar Dawod, A. Mirghani, .. M. Alkarsani, A. Dafalla, Tajouj Saif Eldin Mohammed, S. Taha, Omer, Saif-Eldin, Elhaj, Abuagla, Gadallah
{"title":"Frequency of Isolation and Antibiotic Resistance Patterns of Bacterial Isolates from Wound Infections, National Cancer Institute, Wad-Medani, Sudan, 2021","authors":"Omer Abu Elhasan Mohammed, Abbakar Dawod, A. Mirghani, .. M. Alkarsani, A. Dafalla, Tajouj Saif Eldin Mohammed, S. Taha, Omer, Saif-Eldin, Elhaj, Abuagla, Gadallah","doi":"10.37319/iqnjm.4.1.11","DOIUrl":null,"url":null,"abstract":"Background: Disturbance of skin integrity (wound) provides a suitable environment for the growth and multiplication of bacteria. The emerging occurrence and spread of multidrug-resistant microbial pathogens present a significant challenge in providing effective health care and is, therefore, a worldwide medical issue.\nAim: The current study reports on the occurrence of possible pathogens associated with wound infections at National Cancer Institute, Wad Madani, Sudan.\nMethodology: This was a cross-sectional descriptive, hospital-based study including 100 patients with wounds suspected to be infected. Suspicion was dependent on the inability of wounds to heal properly. A structured questionnaire was given to the subjects to acquire demographic information (age, gender, marital status) and the history of antibiotics administration. Wound swabs were collected and processed according to standard procedure and isolated bacteria were tested for their antimicrobial susceptibilities through the disc diffusion technique according to the CLSI guidelines.\nResults: Morphological identification revealed that the percentage of gram-positive cocci among the isolates was: S. Aureus (66%), and Streptococci (34%). On the other hand, gram-negative bacilli included the following: E coli (48.1%), Proteus vulgaris (19%), Proteus mirabilis (14%), Klebsiella species (9%), Pseudomonas species (5%) and other bacterial species (4%). Most bacterial isolates exhibited a high rate of resistance to cephalosporin generations (Cefixime (69%), Cefuroxime (49%), Cefotaxime (32%), Ceftriaxone (29%), Cefepime (20%)). The majority of bacterial isolates were sensitive to Meropenem (resistance rate 3%). The antibiogram results of the other antibiotics were as follows: Ciprofloxacin (18%), Gentamicin (16%).\nConclusion: S. Aureus was the most prevalent bacteria among the isolates with a percentage of 66%. The highest rate of resistance was observed among cephalosporin generations, mainly Cefixime and Cefuroxime with resistance rate of 69% and 49%, respectively.\n \n \n ","PeriodicalId":333401,"journal":{"name":"Iraqi National journal of Medicine","volume":"77 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iraqi National journal of Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37319/iqnjm.4.1.11","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1

Abstract

Background: Disturbance of skin integrity (wound) provides a suitable environment for the growth and multiplication of bacteria. The emerging occurrence and spread of multidrug-resistant microbial pathogens present a significant challenge in providing effective health care and is, therefore, a worldwide medical issue. Aim: The current study reports on the occurrence of possible pathogens associated with wound infections at National Cancer Institute, Wad Madani, Sudan. Methodology: This was a cross-sectional descriptive, hospital-based study including 100 patients with wounds suspected to be infected. Suspicion was dependent on the inability of wounds to heal properly. A structured questionnaire was given to the subjects to acquire demographic information (age, gender, marital status) and the history of antibiotics administration. Wound swabs were collected and processed according to standard procedure and isolated bacteria were tested for their antimicrobial susceptibilities through the disc diffusion technique according to the CLSI guidelines. Results: Morphological identification revealed that the percentage of gram-positive cocci among the isolates was: S. Aureus (66%), and Streptococci (34%). On the other hand, gram-negative bacilli included the following: E coli (48.1%), Proteus vulgaris (19%), Proteus mirabilis (14%), Klebsiella species (9%), Pseudomonas species (5%) and other bacterial species (4%). Most bacterial isolates exhibited a high rate of resistance to cephalosporin generations (Cefixime (69%), Cefuroxime (49%), Cefotaxime (32%), Ceftriaxone (29%), Cefepime (20%)). The majority of bacterial isolates were sensitive to Meropenem (resistance rate 3%). The antibiogram results of the other antibiotics were as follows: Ciprofloxacin (18%), Gentamicin (16%). Conclusion: S. Aureus was the most prevalent bacteria among the isolates with a percentage of 66%. The highest rate of resistance was observed among cephalosporin generations, mainly Cefixime and Cefuroxime with resistance rate of 69% and 49%, respectively.      
伤口感染分离细菌的分离频率和抗生素耐药性模式,国家癌症研究所,瓦德-梅达尼,苏丹,2021
背景:皮肤完整性的破坏(创面)为细菌的生长和繁殖提供了适宜的环境。耐多药微生物病原体的出现和传播对提供有效的卫生保健提出了重大挑战,因此是一个全球性的医学问题。目的:本研究报告了苏丹Wad Madani国家癌症研究所与伤口感染相关的可能病原体的发生情况。方法:这是一项以医院为基础的横断面描述性研究,包括100例伤口疑似感染的患者。怀疑建立在伤口无法正常愈合的基础上。对受试者进行结构化问卷调查,获取人口统计信息(年龄、性别、婚姻状况)和抗生素使用史。收集伤口拭子并按标准程序处理,根据CLSI指南通过圆盘扩散技术检测分离细菌的抗菌药物敏感性。结果:形态鉴定显示革兰氏阳性球菌比例为:金黄色葡萄球菌(66%)和链球菌(34%)。革兰氏阴性杆菌包括大肠杆菌(48.1%)、普通变形杆菌(19%)、奇异变形杆菌(14%)、克雷伯氏菌(9%)、假单胞菌(5%)和其他细菌(4%)。大多数细菌分离株对头孢菌素耐药率高(头孢克肟(69%)、头孢呋辛(49%)、头孢噻肟(32%)、头孢曲松(29%)、头孢吡肟(20%))。多数菌株对美罗培南敏感(耐药率3%)。其他抗生素的抗菌谱结果如下:环丙沙星(18%)、庆大霉素(16%)。结论:金黄色葡萄球菌是最常见的分离菌,占66%。各代头孢菌素耐药率最高,以头孢克肟和头孢呋辛为主,耐药率分别为69%和49%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信