The effects of high altitude hypoxia environment on ultrastructure of the rat lung and heart

2011 IEEE International Symposium on IT in Medicine and Education Pub Date : 2011-12-01 DOI:10.1109/ITIME.2011.6132072

L. Wenhua, Gong Jing, D. Yuan

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Abstract

Background: Studies show that rapid access to high altitude, the body inevitably will be different degrees of injury, more significant damage to heart and lung ⌈1 ∼ 3⌉. The high altitude hypo-xia on the heart and lungs to adapt to structural changes of the early rarely been reported so far. From near sea level on the test area to a higher altitude within a short time to bring the heart and lung of rats by light and electron microscopy. Objective: To evaluate hypoxic altitude hypoxia on the ultrastructure of rat heart and lung. Methods: SD rats were randomly divided into 4 groups, namely the plateau 1 d (A group), 3 d (B group), 30 d (C group), the control group (D group in Xi'an area, elevation 5m). Three experimental animals brought by the Golmud, Qinghai, Xi'an time -consuming 1d (elevation 2700m), 3d to the Naqu (elevation 4500m) and 30d Nagqu (elevation 4500m), were sacrificed at different time points, the light and electron microscope cardiopulmonary specimens. Results: Acute hypoxia A, B microstructure and ultrastructure of lung tissue apparent interstitial pulmonary edema and alveolar pulmonary edema, and after hypoxic interstitial pulmonary edema after the C group were significantly reduced; acute hypoxia A, B light microscopy of heart tissue in rats ventricular myocytes were all seen varying degrees of cloudy swelling, vacuolar degeneration, necrosis and interstitial dissolved edema, electron microscope, mitochondria swelling, sarcoplasmic reticulum, myofibril dissolution, intracellular and extracellular edema, acute hypoxia group B compared with the change in left ventricular wall was the right, and after hypoxic interstitial edema after the C group was significantly reduced. Conclusion: SD rats caused by acute hypoxia altitude pulmonary edema and alveolar interstitial pulmonary edema, caused by SD rat heart with right ventricular-based injury, after acclimatization altitude hypoxia significantly reduced after the heart and lung disease.

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高原缺氧环境对大鼠肺、心脏超微结构的影响

背景:研究表明，快速进入高海拔地区，身体不可避免地会受到不同程度的伤害，更显著的是对心肺的损害(1 ~ 3)。高原缺氧对心肺早期适应结构变化的影响迄今鲜有报道。在较短的时间内从接近海平面的试验区到较高的海拔高度，通过光镜和电子显微镜对大鼠的心肺进行观察。目的:探讨低海拔缺氧对大鼠心肺超微结构的影响。方法:SD大鼠随机分为4组，分别为高原1 d (A组)、3 d (B组)、30 d (C组)、对照组(d组在西安地区，海拔5m)。分别从青海格尔木、西安带来的实验动物3只，耗时1d(海拔2700m)， 3d到达那曲(海拔4500m)， 30d到达那曲(海拔4500m)，分别在不同时间点处死，取光镜和电镜心肺标本。结果:急性缺氧A组、B组肺组织超微结构、超微结构明显间质性肺水肿和肺泡性肺水肿，以及缺氧后C组间质性肺水肿均显著减少;急性缺氧A、B光镜下心脏组织大鼠心室肌细胞均可见不同程度的浑浊肿胀、空泡变性、坏死及间质溶解性水肿，电镜下可见线粒体肿胀、肌浆网、肌原纤维溶解、细胞内外水肿，与急性缺氧B组相比，左室壁变化明显，而缺氧后C组间质水肿明显减轻。结论:SD大鼠急性缺氧所致高原肺水肿及肺泡间质性肺水肿，由SD大鼠心脏伴右室基底损伤所致，经高原缺氧适应后的心肺疾病明显减轻。

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2011 IEEE International Symposium on IT in Medicine and Education

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