Electrochemical behavior and determination of ketoprofen at glassy--carbon electrode

Abstract

Ketoprofen (2-(3-benzoylphenyl)-propionic acid) is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic actions, that make it valuable in the treatment of rheumatoid arthritis and to relieve mild to moderate pain (Medina-López, Vara-Gama, SoriaArteche, Moreno-Rocha, & López-Muñoz, 2018) . The widespread and growing medical application needs to be followed by the development of analytical techniques for detection of ketoprofen traces in various body fluids or wastewaters. Several methods have already been reported for quantitative determination of ketoprofen, including chromatography (Emhofer, Himmelsbach, Buchberger, & Klampfl, 2017; Jin, Zhang, Jin, & Lee, 2018), UV-spectrophotometric (M. Blanco, Coello, Iturriaga, Maspoch, & Alaoui-Ismaili, 1997), capillary electrophoresis (Marcelo Blanco, González, Torras, & Valverde, 2003) and fluorescence (Maciążek-Jurczyk, 2014; Molina-García, Santos, Ruiz-Medina, & LlorentMartínez, 2013). Application of all these methods is timeconsuming and require numerous sample pretreatment steps. Electrochemical methods have a number of advantages like high selectivity and sensitivity or simple design of the analytical equipment. Electrochemical studies of ketoprofen have already been performed using mercury drop (Ghoneim & Tawfik, 2003), boron-doped diamond (Domínguez, González, Palo, & SánchezMartín, 2010) or platinum electrode (Muthu, Latha, G.Bhaskar, & Yoshihara, 2010) and recently indium tin oxide (ITO)-coated optical fiber sensor (Bogdanowicz et al., 2018). The aim of the present work was determine the electrochemical behavior of ketoprofen analyzed at glassy-carbon electrode. The limit of detection of ketoprofen was calculated.