ACTIVATED PROTEIN C RESISTANCE, ENDOGENOUS ANTICOAGULANTS AND COAGULATION PARAMETERS IN RECURRENT PREGNANCY LOSS

G. Öner, I. Muderris, Ç. Saatçi
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引用次数: 1

Abstract

SUMMARY Objective: Recurrent miscarriage is usually defined as three or more consecutive miscarriages before 20 weeks and it occurs in 0.5%-1% of total pregnancies. Therefore, activated protein C resistance (APCR), protein C and S deficiency, antithrombin deficiency is important pathologies for RPL. In this study, our aim was to assess the role of thrombophilia parameters in RPL. Material and methods: 35 patients with RPL and 53 healthy control withot RPL were included in this study. Exclusion criterias of this study were uterin anomalies, chronic systemic disease, antiphospholipid and anticardiolipin antibodies entity that caused RPL. Results: There was no difference between two groups for ages. The mean pregnacy loss of 35 patients with RPL was 3.57 ± 1.54 (3-11 items). When patients were compared for the APC resistance, there was a significant difference between the groups. Although the values of protein C, protein S and antithrombin III were low, there was no statistically significant difference between groups. Conclusion: Thrombophilia including APC resistance, protein C and S deficiency, antithrombin deficiency is associated with RPL. Thrombophilia is consequential for the prognosis of pregnancy and is considered for the following of pregnancy in patients with pregnancy.
活化蛋白c抵抗,内源性抗凝剂和凝血参数在复发性妊娠丢失
目的:复发性流产通常定义为20周前连续三次或以上的流产,发生率为总妊娠的0.5%-1%。因此,活化蛋白C抵抗(APCR)、蛋白C和S缺乏、抗凝血酶缺乏是RPL的重要病理。在这项研究中,我们的目的是评估血栓形成参数在RPL中的作用。材料与方法:选取35例RPL患者和53例正常对照。本研究的排除标准为子宫异常、慢性全身性疾病、引起RPL的抗磷脂和抗心磷脂抗体实体。结果:两组患者年龄差异无统计学意义。35例RPL患者的平均妊娠损失为3.57±1.54(3-11项)。当比较患者的APC耐药性时,两组之间存在显著差异。蛋白C、蛋白S、抗凝血酶III值虽低,但组间差异无统计学意义。结论:血栓形成包括APC耐药、蛋白C和S缺乏、抗凝血酶缺乏与RPL相关。血栓形成对妊娠预后有重要影响,并被认为对妊娠患者的后续妊娠有影响。
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