Changes in antibody titres and comparative efficacy of some unconventional remedies in mitigating the effects of infectious bursal disease virus infection in pullet chicks

J. Shallmizhili, P. Abdu, O. Orakpoghenor, T. Markus, A. Andamin, S. Oladele, A. Wakawa
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Abstract

Unconventional remedies are used by farmers against infectious bursal disease (IBD). This study assessed changes in IBD antibody titres and efficacy of some unconventional remedies used by farmers against IBD. Day old ISA brown pullets were assigned into eight groups (A-H) and inoculated with a very virulent IBD virus (vvIBDV) at 21 days of age as follows; group A - administered aqueous leaf extract of Kaya senegalensis (KS); B, C, D, E, and F administered remedies designated as SEV, ENP, ASMS, DLP, and OVX, respectively; G, and H were negative, and positive control, respectively. Changes in IBD antibody (Ab) titres, clinical signs, morbidity and mortality rates, gross lesions, weights and organ ratios of bursal (BF), spleen (S) and thymus (T) were assessed. There were protective levels of Ab in groups of chicks at 2 and 7 days of age. SEV and ASMS potentiated Ab response to vvIBDV; SEV mitigated the severity of clinical signs, morbidity and mortality rates, gross lesions and changes in body and BF weights and SBR; KS clinical signs, morbidity and mortality rates, BF weight and BBR; ENP morbidity rate, spleen and thymus weights and TBR; ASMS thymus weight and TBR; DLP gross lesions, BF weight and BBR; OVX body, spleen weights and SBR. The remedies demonstrated varied actions against VVIBDV infection. SEV and KS leaves could be administered at the onset of IBD outbreak and before IBD vaccination. Processing of KS leaves to reduce concentration of antimetabolites is recommended.
一些非常规疗法对减轻雏鸡传染性法氏囊病病毒感染影响的抗体效价变化和比较效果
农民使用非常规疗法治疗传染性法氏囊病。这项研究评估了IBD抗体滴度的变化和农民使用的一些非常规疗法对抗IBD的效果。将日龄ISA棕色小鸡分为8组(a - h),在21日龄接种极强毒力IBD病毒(vvIBDV);A组给予塞内加尔香树叶水提液;B、C、D、E和F组分别给予SEV、ENP、ASMS、DLP和OVX;G和H分别为阴性对照和阳性对照。评估IBD抗体(Ab)滴度、临床体征、发病率和死亡率、大体病变、法氏囊(BF)、脾脏(S)和胸腺(T)的重量和器官比例的变化。2日龄和7日龄各组雏鸡Ab水平均达到保护水平。SEV和ASMS增强Ab对vvIBDV的反应SEV减轻了临床症状的严重程度、发病率和死亡率、大体病变以及身体和BF重量和SBR的变化;KS临床症状、发病率和死亡率、BF体重和BBR;ENP发病率、脾脏和胸腺重量与TBR;胸腺重量与TBR;DLP大体病变、BF重、BBR;OVX体、脾脏重量和SBR。这些补救措施对VVIBDV感染表现出不同的作用。SEV叶和KS叶可在IBD爆发时和IBD疫苗接种前施用。建议对紫苏叶进行处理,以降低抗代谢物的浓度。
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