Therapeutic Intervention for Restoration of Sensory and Motor Function after Central Nervous System Injury

Abstract

The objective of this study was to investigate the effects of extracorporeal shock wave therapy, on the expression of neurotrophin-3, and C-Fos in the central nervous system injury of rats. In this study, 16 eight-week-old, Sprague-Dawley origin male white rats weighing 250-300g were tested. For low intensity extracorporeal shock wave therapy, a magnetic-type extracorporeal shock wave therapy equipment (HAEMIL, Soltar, Korea) was used. ESWT was applied to the gastrocnemius muscle of the injuried side hind limb. Western blot analysis was analyzed for the evaluation of the NT-3, and C-Fos. Before the experiment, the spinal cords of the experimental and control groups were extracted and pre-evaluated. Spinal cords were extracted after all experiments to extract neurotrophic factors from the experimental and control groups. The change amount of NT-3 and C-Fos expression was statistically significantly difference in the ESWT group that received shock wave compared to the control group. In the comparison of treatment effects of the therapeutic methods, the experimental group showed a significant larger change compared to the control group.