ANTI-OXLDL ANTIBODIES, HOMOCYSTEINE AND APOLIPOPROTEINS IN PRIMARY ANTIPHOSPHOLIPID SYNDROME

Abstract

Summary: The aim of this study was to investigate the influence of: autoantibodies (anticardiolipin, antioxLDL, anti-b2gpI, lupus anticoagulant), apolipoproteins (apo) AI and apoB, and homocysteine on the clinical features of patients with primary antiphospholipid syndrome, and to compare analyzed parameters with those from control subjects. Patients who were positive for anti-oxLDL antibodies had venous thrombosis associated with lower levels of apolipoprotein AI (p < 0.05). Patients with a history of thrombosis of peripheral arterial blood vessels had higher concentrations of apo B (p < 0.05) and this finding was also present in patients with a history of cerebrovascular insults (p < 0.05). Patients with myocardial infarction had significantly higher concentrations of homocysteine (p < 0.05). In patients with PAPS, testing the above-mentioned parameters is justified.