ANALYSIS OF APO-B SERUM LEVELS IN BALB/C MICE HYPERCHOLESTEROLEMIC AGAINST TEMULAWAK EXTRACT (Curcuma xanthoriza Roxb)

Riyadatus Solihah, M. Haris, Y. Abror
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Abstract

APO–B Serum levels is the most predictive value for the incidence of atherosclerosis and coronary heart disease. Curcuma xanthorrhiza Roxb contains curcumin, which can be used as an antioxidant, anti–inflammatory and antihypercholesterol. The mechanism of curcumin contained in ginger to reduce cholesterol is due to its function as a cholagoga or bile stimulant. This study aims to determine the effect of temulawak extract on the levels of APO–B Serum in hypercholesterolemia mice. This research were a true experimental study with a post–test only control group design carried out in February 2018. The extraction As much as 25 mice were divided into 5 groups where are group consisted of 5 mice. Positive control group (K+) were treated with high cholesterol feed and water, negative control group (K–) were given standard feed and water, treatment group 1 (P1) were given high cholesterol food and 25mg/kg BW of curcuma extract for 14 days, treatment group 2 (P2) were treated with foods high in cholesterol and 50mg/kg BW of curcuma extract for 14 days and treatment group 3 (P3) treated with high cholesterol and ginger extract 75mg/kg BW for 14 days. Examination of APO–B levels were measured using the spectrophotometric method. Data were analyzed using One–Way Anova. The results showed that the average of APO–B level at (K+) was 209.7 ± 1.02 mg / dL, at (K–) 115.3 ± 1.04 mg / dL, at (P1) 180.4 ± 1.07 mg / dL, at (P2) 147.6 ± 1.12 mg / dL, at (P3) 119.1 ± 1.10 mg / dL. Based on the results of statistical test it was found that there was a significant decrease in APO–B levels with p–value= 0.001 at alpha 0.05 (p
姜黄提取物对高胆固醇血症BALB/C小鼠血清载脂蛋白b水平的影响
血清APO-B水平是动脉粥样硬化和冠心病发病率的最具预测价值。姜黄含有姜黄素,可以作为抗氧化剂,抗炎和抗高胆固醇。生姜中姜黄素降低胆固醇的机制是由于它具有促胆汁或胆汁的功能。本研究旨在探讨地木醒提取物对高胆固醇血症小鼠血清APO-B水平的影响。这项研究是一项真正的实验研究,仅在2018年2月进行了测试后的对照组设计。将25只小鼠分成5组,每组5只。阳性对照组(K+)饲喂高胆固醇饲料和水,阴性对照组(K -)饲喂标准饲料和水,处理1组(P1)饲喂高胆固醇食物和姜黄提取物25mg/kg BW,连续14 d,处理2组(P2)饲喂高胆固醇食物和姜黄提取物50mg/kg BW,连续14 d,处理3组(P3)饲喂高胆固醇食物和姜黄提取物75mg/kg BW,连续14 d。用分光光度法测定APO-B水平。数据分析采用单因素方差分析。结果表明,(K+)、(K -)、(P1)、(P2)、(147.6±1.12)、(P3) APO-B水平分别为209.7±1.02 mg / dL、115.3±1.04 mg / dL、119.1±1.10 mg / dL。根据统计检验结果,APO-B水平显著降低,p值= 0.001,alpha 0.05 (p
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