Molecular mechanisms associated with ferroptosis during various pulmonary disorders and the possible therapeutic regimens for lung cancer.

Abstract

: Cell death is the natural process in which the old or unwanted cell is damaged and replaced by a newly functional one. Several factors trigger cell death and there are several mechanisms for this event such as apoptosis, autophagy, and ferroptosis. Ferroptosis as a novel type of programmed cell death is occurred due to cellular iron accumulation and the depletion in one of cellular antioxidant enzymes which is glutathione peroxidase 4 (GPX-4). Therefore, ferroptosis is characterized by lipid peroxidation and oxidative stress. Several metabolic pathways such as iron, amino acids, lipids metabolism, etc are considered as regulators for ferroptosis process. Several studies have proved the involvement of ferroptosis in lung diseases progression/depression that range from acute lung injury (ALI) to