Biochemical IC chip toward cell free DNA protein synthesis

Proceedings MEMS 98. IEEE. Eleventh Annual International Workshop on Micro Electro Mechanical Systems. An Investigation of Micro Structures, Sensors, Actuators, Machines and Systems (Cat. No.98CH36176 Pub Date : 1998-01-25 DOI:10.1109/MEMSYS.1998.659742

K. Ikuta, S. Maruo, Y. Fukaya, T. Fujisawa

引用次数: 33

Abstract

The several type of biochemical IC chips with photo detective micro reactor has been developed. The real time monitoring and controlling cell free synthesis of protein was demonstrated successfully. The photo protein of firefly so called Luciferase was synthesized. The biochemical luminescence was monitored by built-in photo diode in the micro reactor to transfer reaction status into voltage signal. Feedback control synthetic reaction was verified experimentally. The results achieved here should be key technology for future DNA and RNA synthesis without biological cell.

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用于细胞游离DNA蛋白合成的生化IC芯片

研制了几种具有光电探测微反应器的生化集成电路芯片。成功地实现了对细胞游离蛋白合成的实时监测和控制。合成了萤火虫的光蛋白荧光素酶。微反应器内内置光电二极管监测生化发光，将反应状态转化为电压信号。实验验证了反馈控制合成反应。本研究成果将成为未来非生物细胞DNA和RNA合成的关键技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Proceedings MEMS 98. IEEE. Eleventh Annual International Workshop on Micro Electro Mechanical Systems. An Investigation of Micro Structures, Sensors, Actuators, Machines and Systems (Cat. No.98CH36176

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