Toxicological support of simulation of the chemical composition modelling of bioactive substances in natural honey

Abstract

ABSTRACT. In the context of increasing anthropogenic load, the ability of the body to maintain high-level resistance to various harmful factors is essential. Thus, the creation of effective tools that can increase the level of adaptive capacity of the human body under conditions of the environmental hazards is a topical issue of modern medicine. Objective. Scientific substantiation of the technology of creation of enriched natural honey containing bioactive substances — adaptogens, capable to increase adaptive capabilities of the body under conditions of environmental hazards. Materials and Methods. The material for this study were Ukrainian breed bees. The process of enriching the natural properties of natural honey was carried out in a natural way through the bee family, by feeding colonies of bees with a special composition of natural origin components based on common oat (Avtina satHva) and milk thistle (Silybum marianum). Results. The analysis of the regulatory framework governing the use of honey with phytoadditives and bee products in Ukraine has proved that currently there is a lack of scientifically grounded technology of natural honey enrichment, which is realized through the bee family by feeding optimally selected qualitative and quantitative composition of high-quality components of natural origin. The authors proposed a model of toxicological and hygienic evaluation of raw materials and finished product based on enriched natural honey, which allows carrying out toxicological support of the process of creating an innovative product — enriched natural honey, and developing a modern technological standard of the finished product according to the evaluation results. Study results have proved that the most promising medicinal raw material for the creation of enriched natural honey is milk thistle (Silybum marianum) extract. Conclusion. The results of the first stage of the study confirm the prospect of further research on natural adaptogens for the development of innovative products based on natural honey and bioactive substances of plant origin, which will allow obtaining new useful varieties of honey and significantly improving the economic performance of enterprises producing these products. Key Words: biotechnologies, honey, bioactive substances, adaptogens.