The novel use of convalescent plasma in patients with COVID 19 in Basra governorate, Case series review

Iraqi National journal of Medicine Pub Date : 2020-05-06 DOI:10.37319/iqnjm.2.csi.1

Saad Hammadi Prof, Ali Hashim prof, Abbas Ali Dr, Rafid Abbood Dr, Hassanein Ali Dr, Ali Abdullah Dr, Ali Kadhim Dr, Amjed Rodeen Dr, Hiba Ashoor Dr, Shaw Dr, Basim Abdulhassan Dr, Mustafa Mawih

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引用次数: 1

Abstract

Background: The idea of convalescent plasma usage is to give passive immunity to the patients, so their immune system stands a good chance of combating the virus.this study will review 6 cases of eligible covid 19 patients that had been treated with convalescent plasma therapy in Basra covid 19 quarantine Objectives: to demonstrate efficacy and safety of convalescent plasma in the patient series that had been enrolled . Method: this study had pioneered a new method to collect up to 3,000 mL in one session by an off-label use of Spectra Optia Apheresis systems by TerumoBCT /Exchange set to collect convalescent plasma. In this study 250 mL convalescent plasma had been given each of the 6 patients, from one donor. respose in spo2,dyspnoea and tachypnoea was observed ,any reaction to plasma also had been monitored . Result: Our case series have demonstrated both safety and effectiveness of convalescent plasma. This study was successful in reaching our primary and secondary outcomes in all 6 patients (improvement in SpO2 and symptoms). With negligible difference in time of post transfusion response Conclusion: convalescent plasma is apperantly safe and effective, In this study 250 mL convalescent plasma had been given each of the 6 patients, from one donor using Therapeutic Plasma Exchange (TPE) protocol by Spectra Optia Apheresis system/TerumoBCT. Keywords: convalescent plasma, COVID-19, SARS CoV-2, apheresis, plasma exchange, plasma donation

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巴士拉省COVID - 19患者恢复期血浆的新用途:病例系列回顾

背景:恢复期血浆的使用是为了给患者提供被动免疫，使他们的免疫系统有很好的机会对抗病毒。本研究将审查6例符合条件的在巴士拉covid - 19检疫中接受恢复期血浆治疗的covid - 19患者。目的:证明已入组的患者系列恢复期血浆的有效性和安全性。方法:本研究开创了一种新方法，通过超说明书使用TerumoBCT /Exchange set的Spectra Optia Apheresis系统收集恢复期血浆，每次最多可收集3,000 mL。在这项研究中，6例患者每人给予250 mL的恢复期血浆，来自一个供体。观察患者对spo2的反应，呼吸困难和呼吸急促，并监测血浆的反应。结果:我们的病例系列证明了恢复期血浆的安全性和有效性。该研究成功地达到了所有6例患者的主要和次要结局(SpO2和症状的改善)。结论:恢复期血浆明显是安全有效的，本研究采用治疗性血浆交换(TPE)方案，由Spectra Optia Apheresis系统/TerumoBCT对6例患者各给予250 mL恢复期血浆。关键词:恢复期血浆，COVID-19, SARS - CoV-2，血浆分离，血浆交换，血浆捐献

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Iraqi National journal of Medicine

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