Rusul Ali Al-Masaoodi, Alaauldeen S. M. Al-Sallami, H. Al-Baseesee
{"title":"The relation between the RANKL and resistin in menopausal women with osteoporosis","authors":"Rusul Ali Al-Masaoodi, Alaauldeen S. M. Al-Sallami, H. Al-Baseesee","doi":"10.1063/1.5123113","DOIUrl":null,"url":null,"abstract":"Osteoporosis (OP) is osteometabolic disease characterized by a decrease in bone mineral density(BMD) and due to the deterioration of bone architecture leading to spontaneous fractures. The aim of the current study is to evaluate the biomarkers include the; receptor activator of nuclear factor NF-κB ligand and Resistin, also measuring the biochemical include: estrogen, calcium, phosphorus, bone mineral density, t-scores in menopausal women with osteoporosis, and further more study the correlation between these biomarkers and biochemical. Method : This study was conducted at DEXA (dual-energy x-ray absorptiometry) Unit in Radiology Department in Al-Sader teaching hospital in AL-Najaf province /Iraq from January2018 to July 2018 to know the prevalence of osteoporosis in Iraqi menopausal women. A total of the (88) women involved in this study, blood samples had been taken from the (68) osteoporosis menopausal women, and from (20) women who were apparently healthy as a control group. Assays of study estimation of the parameters levels that include: Calcium, phosphorous were done by using auto biochemistry analyzer; Receptor activator of nuclear factor NF-κB ligand bone alkaline phosphatase, Resistin and estrogen, were measurement by using a solid phase enzyme-linked immunosorbent assay (ELISA). Result: The result of study showed a significant decrease (p < 0.05) in concentration of serum estrogen, calcium and phosphorus in menopausal women with osteoporosis compared with healthy group. The biomarker revealed a significant increase (p < 0.05) in the concentration of receptor activator of nuclear factor NF-κB ligand and Resistin in menopausal women with osteoporosis compared with healthy group. The study exhibited correlation coefficient and showed a significant (p < 0.05) negative correlation between BMD and receptor activator of nuclear factor NF-κB ligand. The study showed a significant negative (p < 0.05) correlation between estrogen and of nuclear factor NF-κB ligand. This study show significant (p < 0.05) positive correlation of receptor activator of nuclear factor NF-κB ligand with resistin.Osteoporosis (OP) is osteometabolic disease characterized by a decrease in bone mineral density(BMD) and due to the deterioration of bone architecture leading to spontaneous fractures. The aim of the current study is to evaluate the biomarkers include the; receptor activator of nuclear factor NF-κB ligand and Resistin, also measuring the biochemical include: estrogen, calcium, phosphorus, bone mineral density, t-scores in menopausal women with osteoporosis, and further more study the correlation between these biomarkers and biochemical. Method : This study was conducted at DEXA (dual-energy x-ray absorptiometry) Unit in Radiology Department in Al-Sader teaching hospital in AL-Najaf province /Iraq from January2018 to July 2018 to know the prevalence of osteoporosis in Iraqi menopausal women. A total of the (88) women involved in this study, blood samples had been taken from the (68) osteoporosis menopausal women, and from (20) women who were apparently healthy as a control group. Assays of study estimation...","PeriodicalId":225684,"journal":{"name":"THE 7TH INTERNATIONAL CONFERENCE ON APPLIED SCIENCE AND TECHNOLOGY (ICAST 2019)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"THE 7TH INTERNATIONAL CONFERENCE ON APPLIED SCIENCE AND TECHNOLOGY (ICAST 2019)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1063/1.5123113","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
Osteoporosis (OP) is osteometabolic disease characterized by a decrease in bone mineral density(BMD) and due to the deterioration of bone architecture leading to spontaneous fractures. The aim of the current study is to evaluate the biomarkers include the; receptor activator of nuclear factor NF-κB ligand and Resistin, also measuring the biochemical include: estrogen, calcium, phosphorus, bone mineral density, t-scores in menopausal women with osteoporosis, and further more study the correlation between these biomarkers and biochemical. Method : This study was conducted at DEXA (dual-energy x-ray absorptiometry) Unit in Radiology Department in Al-Sader teaching hospital in AL-Najaf province /Iraq from January2018 to July 2018 to know the prevalence of osteoporosis in Iraqi menopausal women. A total of the (88) women involved in this study, blood samples had been taken from the (68) osteoporosis menopausal women, and from (20) women who were apparently healthy as a control group. Assays of study estimation of the parameters levels that include: Calcium, phosphorous were done by using auto biochemistry analyzer; Receptor activator of nuclear factor NF-κB ligand bone alkaline phosphatase, Resistin and estrogen, were measurement by using a solid phase enzyme-linked immunosorbent assay (ELISA). Result: The result of study showed a significant decrease (p < 0.05) in concentration of serum estrogen, calcium and phosphorus in menopausal women with osteoporosis compared with healthy group. The biomarker revealed a significant increase (p < 0.05) in the concentration of receptor activator of nuclear factor NF-κB ligand and Resistin in menopausal women with osteoporosis compared with healthy group. The study exhibited correlation coefficient and showed a significant (p < 0.05) negative correlation between BMD and receptor activator of nuclear factor NF-κB ligand. The study showed a significant negative (p < 0.05) correlation between estrogen and of nuclear factor NF-κB ligand. This study show significant (p < 0.05) positive correlation of receptor activator of nuclear factor NF-κB ligand with resistin.Osteoporosis (OP) is osteometabolic disease characterized by a decrease in bone mineral density(BMD) and due to the deterioration of bone architecture leading to spontaneous fractures. The aim of the current study is to evaluate the biomarkers include the; receptor activator of nuclear factor NF-κB ligand and Resistin, also measuring the biochemical include: estrogen, calcium, phosphorus, bone mineral density, t-scores in menopausal women with osteoporosis, and further more study the correlation between these biomarkers and biochemical. Method : This study was conducted at DEXA (dual-energy x-ray absorptiometry) Unit in Radiology Department in Al-Sader teaching hospital in AL-Najaf province /Iraq from January2018 to July 2018 to know the prevalence of osteoporosis in Iraqi menopausal women. A total of the (88) women involved in this study, blood samples had been taken from the (68) osteoporosis menopausal women, and from (20) women who were apparently healthy as a control group. Assays of study estimation...