The relation between the RANKL and resistin in menopausal women with osteoporosis

Rusul Ali Al-Masaoodi, Alaauldeen S. M. Al-Sallami, H. Al-Baseesee
{"title":"The relation between the RANKL and resistin in menopausal women with osteoporosis","authors":"Rusul Ali Al-Masaoodi, Alaauldeen S. M. Al-Sallami, H. Al-Baseesee","doi":"10.1063/1.5123113","DOIUrl":null,"url":null,"abstract":"Osteoporosis (OP) is osteometabolic disease characterized by a decrease in bone mineral density(BMD) and due to the deterioration of bone architecture leading to spontaneous fractures. The aim of the current study is to evaluate the biomarkers include the; receptor activator of nuclear factor NF-κB ligand and Resistin, also measuring the biochemical include: estrogen, calcium, phosphorus, bone mineral density, t-scores in menopausal women with osteoporosis, and further more study the correlation between these biomarkers and biochemical. Method : This study was conducted at DEXA (dual-energy x-ray absorptiometry) Unit in Radiology Department in Al-Sader teaching hospital in AL-Najaf province /Iraq from January2018 to July 2018 to know the prevalence of osteoporosis in Iraqi menopausal women. A total of the (88) women involved in this study, blood samples had been taken from the (68) osteoporosis menopausal women, and from (20) women who were apparently healthy as a control group. Assays of study estimation of the parameters levels that include: Calcium, phosphorous were done by using auto biochemistry analyzer; Receptor activator of nuclear factor NF-κB ligand bone alkaline phosphatase, Resistin and estrogen, were measurement by using a solid phase enzyme-linked immunosorbent assay (ELISA). Result: The result of study showed a significant decrease (p < 0.05) in concentration of serum estrogen, calcium and phosphorus in menopausal women with osteoporosis compared with healthy group. The biomarker revealed a significant increase (p < 0.05) in the concentration of receptor activator of nuclear factor NF-κB ligand and Resistin in menopausal women with osteoporosis compared with healthy group. The study exhibited correlation coefficient and showed a significant (p < 0.05) negative correlation between BMD and receptor activator of nuclear factor NF-κB ligand. The study showed a significant negative (p < 0.05) correlation between estrogen and of nuclear factor NF-κB ligand. This study show significant (p < 0.05) positive correlation of receptor activator of nuclear factor NF-κB ligand with resistin.Osteoporosis (OP) is osteometabolic disease characterized by a decrease in bone mineral density(BMD) and due to the deterioration of bone architecture leading to spontaneous fractures. The aim of the current study is to evaluate the biomarkers include the; receptor activator of nuclear factor NF-κB ligand and Resistin, also measuring the biochemical include: estrogen, calcium, phosphorus, bone mineral density, t-scores in menopausal women with osteoporosis, and further more study the correlation between these biomarkers and biochemical. Method : This study was conducted at DEXA (dual-energy x-ray absorptiometry) Unit in Radiology Department in Al-Sader teaching hospital in AL-Najaf province /Iraq from January2018 to July 2018 to know the prevalence of osteoporosis in Iraqi menopausal women. A total of the (88) women involved in this study, blood samples had been taken from the (68) osteoporosis menopausal women, and from (20) women who were apparently healthy as a control group. Assays of study estimation...","PeriodicalId":225684,"journal":{"name":"THE 7TH INTERNATIONAL CONFERENCE ON APPLIED SCIENCE AND TECHNOLOGY (ICAST 2019)","volume":"25 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"THE 7TH INTERNATIONAL CONFERENCE ON APPLIED SCIENCE AND TECHNOLOGY (ICAST 2019)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1063/1.5123113","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4

Abstract

Osteoporosis (OP) is osteometabolic disease characterized by a decrease in bone mineral density(BMD) and due to the deterioration of bone architecture leading to spontaneous fractures. The aim of the current study is to evaluate the biomarkers include the; receptor activator of nuclear factor NF-κB ligand and Resistin, also measuring the biochemical include: estrogen, calcium, phosphorus, bone mineral density, t-scores in menopausal women with osteoporosis, and further more study the correlation between these biomarkers and biochemical. Method : This study was conducted at DEXA (dual-energy x-ray absorptiometry) Unit in Radiology Department in Al-Sader teaching hospital in AL-Najaf province /Iraq from January2018 to July 2018 to know the prevalence of osteoporosis in Iraqi menopausal women. A total of the (88) women involved in this study, blood samples had been taken from the (68) osteoporosis menopausal women, and from (20) women who were apparently healthy as a control group. Assays of study estimation of the parameters levels that include: Calcium, phosphorous were done by using auto biochemistry analyzer; Receptor activator of nuclear factor NF-κB ligand bone alkaline phosphatase, Resistin and estrogen, were measurement by using a solid phase enzyme-linked immunosorbent assay (ELISA). Result: The result of study showed a significant decrease (p < 0.05) in concentration of serum estrogen, calcium and phosphorus in menopausal women with osteoporosis compared with healthy group. The biomarker revealed a significant increase (p < 0.05) in the concentration of receptor activator of nuclear factor NF-κB ligand and Resistin in menopausal women with osteoporosis compared with healthy group. The study exhibited correlation coefficient and showed a significant (p < 0.05) negative correlation between BMD and receptor activator of nuclear factor NF-κB ligand. The study showed a significant negative (p < 0.05) correlation between estrogen and of nuclear factor NF-κB ligand. This study show significant (p < 0.05) positive correlation of receptor activator of nuclear factor NF-κB ligand with resistin.Osteoporosis (OP) is osteometabolic disease characterized by a decrease in bone mineral density(BMD) and due to the deterioration of bone architecture leading to spontaneous fractures. The aim of the current study is to evaluate the biomarkers include the; receptor activator of nuclear factor NF-κB ligand and Resistin, also measuring the biochemical include: estrogen, calcium, phosphorus, bone mineral density, t-scores in menopausal women with osteoporosis, and further more study the correlation between these biomarkers and biochemical. Method : This study was conducted at DEXA (dual-energy x-ray absorptiometry) Unit in Radiology Department in Al-Sader teaching hospital in AL-Najaf province /Iraq from January2018 to July 2018 to know the prevalence of osteoporosis in Iraqi menopausal women. A total of the (88) women involved in this study, blood samples had been taken from the (68) osteoporosis menopausal women, and from (20) women who were apparently healthy as a control group. Assays of study estimation...
绝经期骨质疏松妇女RANKL与抵抗素的关系
骨质疏松症(OP)是一种骨代谢疾病,其特征是骨密度(BMD)下降,由于骨结构恶化导致自发性骨折。本研究的目的是评估生物标志物包括;受体激活因子核因子NF-κB配体和抵抗素,同时测定绝经期骨质疏松妇女的生化指标包括:雌激素、钙、磷、骨密度、t评分,并进一步研究这些生物标志物与生化指标的相关性。方法:本研究于2018年1月至2018年7月在伊拉克AL-Najaf省Al-Sader教学医院放射科DEXA(双能x线吸收仪)单元进行,了解伊拉克绝经期妇女骨质疏松症的患病率。共有88名妇女参与了这项研究,其中68名患有骨质疏松症的绝经期妇女和20名明显健康的妇女的血液样本作为对照组。研究参数的测定包括:钙、磷的测定采用自动生化分析仪进行;采用固相酶联免疫吸附试验(ELISA)检测核因子NF-κB配体受体激活剂骨碱性磷酸酶、抵抗素和雌激素水平。结果:与健康组相比,绝经期骨质疏松妇女血清雌激素、钙、磷浓度显著降低(p < 0.05)。生物标志物显示,与健康组相比,绝经期骨质疏松妇女核因子NF-κB配体受体激活剂和抵抗素浓度显著升高(p < 0.05)。本研究显示骨密度与核因子NF-κB受体激活剂配体呈显著负相关(p < 0.05)。研究显示雌激素与核因子NF-κB配体呈显著负相关(p < 0.05)。本研究显示核因子受体激活剂NF-κB配体与抵抗素呈正相关(p < 0.05)。骨质疏松症(OP)是一种骨代谢疾病,其特征是骨密度(BMD)下降,由于骨结构恶化导致自发性骨折。本研究的目的是评估生物标志物包括;受体激活因子核因子NF-κB配体和抵抗素,同时测定绝经期骨质疏松妇女的生化指标包括:雌激素、钙、磷、骨密度、t评分,并进一步研究这些生物标志物与生化指标的相关性。方法:本研究于2018年1月至2018年7月在伊拉克AL-Najaf省Al-Sader教学医院放射科DEXA(双能x线吸收仪)单元进行,了解伊拉克绝经期妇女骨质疏松症的患病率。共有88名妇女参与了这项研究,其中68名患有骨质疏松症的绝经期妇女和20名明显健康的妇女的血液样本作为对照组。研究评估的分析…
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信