Could the Next Antibiotic Emerge from Bacteria?

Abstract

An intrinsic bacterial mechanism could play a fundamental role in the future of antibiotics. Using cryo-EM, the structural resolution of the effector protein complexed with its chaperone and other accessory proteins reveals the mechanism of action of type VI bacterial secretion system. The importance of the chaperone protein, used to prime the toxic effector protein, was previously identified. Future research efforts should encompass the immunity protein that may allow bacteria to evade the lethal effects of this mechanism.