The variation of the systemic immune-inflammation index in patients with Vitamin D deficiency

Abstract

In this study, the variability of the systemic immune inflammation index (SII), which is accepted as a new marker of inflammation, was investigated in patients with vitamin D deficiency. Biochemical and complete blood count data of outpatients were scanned and recorded retrospectively from digital data. SII was calculated for each patient based on whole blood parameters (neutrophil x platelet/lymphocyte). The relationship between SII and vitamin D variation was investigated. The mean age of the 113 patients included in the study was 38.58±12.37 years. Mean levels of vitamin D, B12 and folate were 13.68±6.57 ng/ml, 309.54±110.73 pg/ml and 7.13±2.77 ng/ml, respectively. The mean SII was 434.39±156.72. Vitamin D was below 10 ng/mL in 38 patients (33.6%). It was between 10-20 ng/mL in 56 patients (49.5%) and 20 ng/mL and above in 19 patients (16.8%). Vitamin B12 was significantly lower in the primary group than in the secondary group (p0.05). Vitamin D deficiency is one of the most common health problems. Possible relationships between vitamin D deficiency and inflammation are still under investigation. In this study, we wanted to evaluate the SII variation in patients with vitamin D deficiency, but we could not find any association.