Biochemical biomarkers for detection of nephrotoxicity and cardiotoxicity in cisplatin administered rats.

Journal of Dr. Behcet Uz Children's Hospital Pub Date : 2013-07-31 DOI:10.5222/buchd.2013.105

A. Çolak, B. Toprak, H. Yalcin, Z. Altun, G. Diniz, Aybüke Olgun, O. Yılmaz, S. Aktaş

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引用次数: 1

Abstract

Objective: Cisplatin is a widely used anticancer drug. The aim of this study is to investigate biochemical biomarkers that can be used for identification of cisplatin cardiotoxicity and nephrotoxicity. Methods: This study was conducted on female Wistar Albino rats weighing 200-300 g. Rats were seperated into two groups as cisplatin administered group (n=5) and the control group (n=6). Intraperitoneal cisplatin (cumulative dose 16 mg/kg) was administered to the first group and the second group received physiological serum. All rats were sacrificed on day 14 of the study. BNP, troponın I, CK MB, urea, creatinine levels were measured in rat blood samples. All blood samples were stored at -80°C until measurement. Results: Troponın I, urea and creatinine concentrations of cisplatin administered rats were signicantly higher from those of the control rats. Conclusion: Urea and creatinine values may be used for identification of cisplatin nephrotoxicity and troponın I may be a good biomarker for detection of cisplatin cardiotoxicity.

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用生化生物标志物检测顺铂大鼠肾毒性和心脏毒性。

目的:顺铂是一种应用广泛的抗癌药物。本研究的目的是研究可用于鉴定顺铂心脏毒性和肾毒性的生化生物标志物。方法:以体重200 ~ 300 g的雌性Wistar白化大鼠为实验对象。将大鼠分为两组，顺铂治疗组(n=5)和对照组(n=6)。第一组腹腔注射顺铂(累积剂量16 mg/kg)，第二组腹腔注射生理血清。实验第14天处死所有大鼠。测定大鼠血样中BNP、troponın I、CK MB、尿素、肌酐水平。所有血液样本保存在-80°C直到测量。结果:Troponın顺铂组大鼠I、尿素和肌酐浓度明显高于对照组大鼠。结论:尿素和肌酐值可用于顺铂肾毒性的鉴定，troponın I可作为顺铂心脏毒性检测的良好生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of Dr. Behcet Uz Children's Hospital

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