{"title":"Corticosteroid response of rabbits and rats to exogenous ACTH.","authors":"C Boiti, R S Yalow","doi":"10.1080/07435807809073633","DOIUrl":null,"url":null,"abstract":"<p><p>The dynamics of the alterations of the cortisol: corticosterone ratio in rabbits during porcine ACTH administration were studied on an almost daily basis and as a function of time after injection. In rabbits the cortisol: corticosterone ratio increased strikingly but variably during the treatment period. Rats responded to similar treatment only with increased corticosterone release. The differences are attributed to the presence of 1-39 ACTH as well as intermediate ACTH in the rabbit pituitary but not in the rat pituitary.</p>","PeriodicalId":75821,"journal":{"name":"Endocrine research communications","volume":"5 1","pages":"21-33"},"PeriodicalIF":0.0000,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/07435807809073633","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine research communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/07435807809073633","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 9
Abstract
The dynamics of the alterations of the cortisol: corticosterone ratio in rabbits during porcine ACTH administration were studied on an almost daily basis and as a function of time after injection. In rabbits the cortisol: corticosterone ratio increased strikingly but variably during the treatment period. Rats responded to similar treatment only with increased corticosterone release. The differences are attributed to the presence of 1-39 ACTH as well as intermediate ACTH in the rabbit pituitary but not in the rat pituitary.
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