Interaction of hierarchical nanoporous carbons(HNCs) with chicken embryo red blood cells (RBC)

Abstract

Interaction of hierarchical nanoporous carbons (HNCs) with chicken embryo red blood cells (RBC). The purpose of this study was to characterize toxicity of hierarchical nanoporous carbons (HNCs) on chicken embryo red blood cells (RBC), which are a perfect model to adapt the hemolysis assay in evaluation of the in vitro blood compatibility of nanoparticles. The samples of blood were treated with different concentration of HNCs (10, 50 and 100 μg/ml). Hemolysis assay showed that the hemolytic activity depends on the dose of HNCs. The microscope observations have shown a difference in morphology between treated and untreated RBC: changes in cell membrane shape and the occurrence of pathological