Hypoalbuminemia in COVID-19: Molecular and Mechanistic Approach

Ali Afzal, Sara Shahzaman, Arwa Azam, Usman Ghani, Muhammad Babar Khawar, Nimra Afzal, Muhammad Idnan, Ume Habiba, Muhammad Abu Talha Safdar Hashmi, Syeda Eisha Hamid, Rimsha Naseem
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Abstract

Hypoalbuminemia is a clinical feature of COVID-19 which is caused by a multitude of processes in COVID-19, including acute liver damage (ALI), oxidative burst, viral-albumin binding, dysregulated immunological responses, and viral genome interference in the host cell, all of which lead to organ failure and patient mortality. We used a mechanistic approach to discuss a number of potential molecular mechanisms that cause hypoalbuminemia, as well as some effective treatment methods. As this study employs molecular approaches to characterize hypoalbuminemia, this work is promising in molecular medicine and drug development.
低白蛋白血症在COVID-19:分子和机制方法
低白蛋白血症是COVID-19的一个临床特征,它是由COVID-19的多种过程引起的,包括急性肝损伤(ALI)、氧化破裂、病毒-白蛋白结合、免疫反应失调以及宿主细胞中的病毒基因组干扰,所有这些都会导致器官衰竭和患者死亡。我们使用了一种机制的方法来讨论一些潜在的分子机制,导致低白蛋白血症,以及一些有效的治疗方法。由于本研究采用分子方法表征低白蛋白血症,因此在分子医学和药物开发方面具有广阔的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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