Detectability of brain structure abnormalities related to autism through MRI-derived measures from multiple scanners

IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI) Pub Date : 2014-06-01 DOI:10.1109/BHI.2014.6864366

G. Auzias, Camille Breuil, S. Takerkart, C. Deruelle

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引用次数: 6

Abstract

Multi-site studies utilizing MRI-derived measures from multiple scanners present an opportunity to increase the power of statistical models by pooling data. This represents the potential of detecting finer and more subtle effects related to pathology and is thus very appealing. It remains however unclear whether or not the potential confound introduced by scanner-related variations will devalue the integrity of any result. Specifically, it is crucial to test whether or not the error introduced into brain morphometry descriptors by image properties variations across scanners can exceed the effect of the disease itself. Moreover, evaluating the influence of the scanner on age-related effects in measurements is essential in the context of developmental disorders such as Autism Spectrum Disorders. In this study, we investigated a data-set of anatomical MRI pooled form three different scanners, representing a total of 186 subjects, 97 patients suffering from ASD and 89 controls. We quantitatively assessed the effects of age, pathology and scanner factors on cortical thickness measurements.

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通过多台扫描仪的核磁共振衍生测量来检测与自闭症相关的大脑结构异常

多地点研究利用来自多个扫描仪的核磁共振衍生测量提供了一个机会，通过汇集数据来增加统计模型的能力。这代表了检测与病理相关的更精细和更微妙影响的潜力，因此非常吸引人。然而，目前尚不清楚的是，扫描仪相关变化带来的潜在混淆是否会降低任何结果的完整性。具体来说，至关重要的是要测试通过扫描仪的图像特性变化引入大脑形态测量描述符的误差是否会超过疾病本身的影响。此外，在自闭症谱系障碍等发育障碍的背景下，评估扫描仪对测量中年龄相关效应的影响是必不可少的。在这项研究中，我们调查了来自三种不同扫描仪的解剖学MRI数据集，共代表186名受试者，97名ASD患者和89名对照组。我们定量评估了年龄、病理和扫描仪因素对皮质厚度测量的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI)

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