Age-related aspects of efficiency of auxiliary genesial technologies at the combined forms of infertility

Abstract

The objective: to study the role of age of patients in the estimation of efficiency of auxiliary genesial technologies at the combined forms of infertility. Materials and methods. For the decision of the put purpose we inspected 70 women of genesial age, which made the followings groups: basic (n=30), comparisons (n=30) and control (n=10). To the complex of the conducted researches were included clinical, echographic, endocrinology, morphological, statistical and immunological. Results. With the increase of age of patients the amount of growings follicles goes down appropriately; ovaries of oocyte got during puncture, including mature. One of mechanisms of violation of follicogenesis and oogenesis is a change to the cytokine adjusting of these processes. With the increase of age of patients there is an increase of content in the follicle liquid of ovaries of proinflammatory cytokines. Stimulation of ovaries of гонадотропинами is accompanied by growth of follicles, recruiting and activating of immunocompetency cages with induction of anti-inflammatory, pro inflammatory cytokines and chemokines. A negative role high concentrations can play in blood of estradiol, and also pharmacological preparations which are used during stimulation of ovaries (гонадотропины, agonists and antagonists of gonadotropin-releasing-hormone), and also age of patients. Conclusions. To the informing clinical and anamnestic and hormonal factors which determine the result of cycle of auxiliary genesial technologies for the patients of genesial age with the combined forms of infertility, take: age of patient, index of mass of body, presence of pipe-peritoneal factor of infertility, level free to testosterone in blood, table of contents of progesterone in blood on 20–22 days of menstrual cycle, and also determination in the follicle liquid of ovaries of cytokines. We are rotin the role of age of patients in the estimation of efficiency of auxiliary genesial technologies.