Stem Cells May Differentiate to Microorganisms

A. Salerian
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Abstract

This study advances a previous hypotheses, “Human body may produce bacteria “and proposes that some infections are generated by human stem cells which differentiate to bacteria and fungus. Evidence consistent with the hypotheses that” Stem cells may differentiate to microorganisms” include studies suggesting that Christensenellaceae are heritable, human genetics shape gut microbiome, host genetics control the composition of gut microbiota and Tinea Versicolor skin infections caused by Malassezia species. Furthermore it has been demonstrated that, amniotic fluid, breast tissue and milk, placenta, umbilical cord blood, meconium harbor bacteria that are not contaminants. Because human stem cells have the properties to differentiate to microorganisms, they seem to be the most likely candidates to differentiate to microorganisms. Evidence suggests humans and other complex multi cellular organisms are giant sources of new microorganisms. Further experimental validation of this observation is necessary yet its potential benefits to study novel avenues to combat opportunistic infections may make it worthy of further scientific scrutiny in the near future.
干细胞可能分化为微生物
本研究提出了“人体可能产生细菌”的假说,并提出一些感染是由人类干细胞分化为细菌和真菌产生的。与“干细胞可能分化为微生物”的假设相一致的证据包括:Christensenellaceae是可遗传的,人类遗传学塑造肠道微生物群,宿主遗传学控制肠道微生物群的组成以及马拉色菌引起的花斑癣皮肤感染。此外,已经证明,羊水、乳腺组织和乳汁、胎盘、脐带血、胎粪中含有细菌,而不是污染物。由于人类干细胞具有分化为微生物的特性,它们似乎是最有可能分化为微生物的候选者。有证据表明,人类和其他复杂的多细胞生物是新微生物的巨大来源。对这一观察结果进行进一步的实验验证是必要的,但它对研究对抗机会性感染的新途径的潜在益处可能使其值得在不久的将来进行进一步的科学审查。
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