[Occupational dermatoses due to polyurethane drugs].

Abstract

Twenty cases of occupational dermatoses caused by isocyanates, especially diphenylmethane diisocyanate (MDI), isophorone diisocyanate (IPDI), toluene diisocyanate (TDI) and tri-isocyanate-triphenylmethane are reported. The handling of patch test substances is described. Personal in test laboratories have to be considered as persons at risk. Findings give some evidence for cross-sensitization between MDI and the corresponding diamine diaminodiphenylmethane. Moreover, it is supposed that MDI may give rise to cross-sensitization to p-phenylene diamine and chemically related compounds.