Effect of cerebral microbleeds on hemorrhagic transformation and functional prognosis after intravenous thrombolysis of cerebral infarction

Abstract

Hemorrhagic transformation is a common complication of acute cerebral infarction, and rtPA thrombolytic therapy will increase the risk of hemorrhagic transformation. Cerebral microbleeds (CMBs) have become an important and independent predictor of cerebral hemorrhage. However, it is still controversial whether CMBs increase the risk of intracranial hemorrhage (ICH) and poor prognosis (PFO) after intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS).This review summarizes a number of studies on microbleeds in clinical patients, and discusses whether the presence, number, and distribution of CMBs are related to ICH and PFO after IVT in AIS patients, as well as the significance of CMBs in IVT decision-making in AIS.