How to Develop Bioresponsive MRI Probes Based on Paramagnetic Gd(III) for in vivo Applications

IF 3.4 Q2 CHEMISTRY, ANALYTICAL
Ping Yue, Dr. Goran Angelovski
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引用次数: 0

Abstract

Among the many biological imaging techniques, magnetic resonance imaging (MRI) has been widely adopted for biomedical and clinical diagnostic applications, because of its ability to image deep tissues with high spatiotemporal resolution. Bioresponsive contrast agents are the key to expanding the diagnostic potential of MRI by providing anatomical information and discerning biochemical activity. Recent developments in the field of responsive and gadolinium-based agents have resulted in novel complexes that can sense their chemical microenvironments and thus study various functional processes in the tissue. Herein, we discuss the design and use of Gd(III)-based and bioresponsive MRI contrast agents for specific biological markers such as Ca(II) and Zn(II) cations and zwitterionic amino acid neurotransmitters. Combining their basic physicochemical characteristics with aspects that should be considered for their use in vivo would achieve the desired sensing features and enable their applications in functional molecular imaging to visualize essential biological processes.

Abstract Image

如何开发基于顺磁性Gd(III)的生物反应性MRI探针用于体内应用
在众多的生物成像技术中,磁共振成像(MRI)因其具有高时空分辨率的深层组织成像能力而被广泛应用于生物医学和临床诊断。生物反应造影剂是通过提供解剖信息和辨别生化活性来扩大MRI诊断潜力的关键。响应性和钆基试剂领域的最新发展导致了新的复合物,可以感知其化学微环境,从而研究组织中的各种功能过程。在这里,我们讨论了Gd(III)基和生物反应性MRI造影剂的设计和使用,用于特定的生物标志物,如Ca(II)和Zn(II)阳离子和两性离子氨基酸神经递质。将它们的基本物理化学特性与在体内使用时应考虑的方面结合起来,将实现所需的传感特性,并使它们能够在功能分子成像中应用,以可视化基本的生物过程。
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CiteScore
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