The preparation and characterisation of tasteless core-shell clarithromycin microcapsules.

IF 3 4区医学 Q2 CHEMISTRY, APPLIED

Journal of microencapsulation Pub Date : 2022-11-01 DOI:10.1080/02652048.2022.2146221

Yu Fu, Yunjing Zhu, Xue Liang, Yihan Kong, Xiaolin Wang, Anan Zhang, Zhiqing Zhao, Jingxin Gou, Yanjiao Wang, Tian Yin, Yu Zhang, Haibing He, Xing Tang

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Abstract

This study aims to fabricate core-shell clarithromycin (CAM) microcapsules to cover up the bitter taste of CAM by spray drying with aqueous polymer dispersion. Water dispersion of Eudragit EPO and Surelease^® were innovatively used to encapsulate CAM into microcapsules via a one-step spray-drying method. The inlet air temperature, airflow rate, CAM-polymer ratio, and particle size of CAM were optimised based on drug content and T_6% (the time taken for the drug to release equal to 6% w/w). The powder properties were assessed by measuring particle size and microstructure using SEM, FT-IR, and PXRD. Furthermore, selected batch was assessed for their drug content, encapsulation efficiency, in vitro release, bitterness, and stability studies. EPO-Surelease^® (1: 4) microcapsules had an average diameter (D50) of 37.69 ± 3.61 μm with a span of 2.395. The drug contents and encapsulation efficiency of EPO-Surelease^®(1:4) were 10.89% and 63.7%, respectively. EPO-Surelease^® (1:4) microcapsules prepared by spray drying with aqueous polymer dispersion can effectively mask the bitter taste of CAM.

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无味核壳克拉霉素微胶囊的制备与表征。

本研究的目的是利用聚合物水分散体喷雾干燥的方法制备芯壳型克拉霉素微胶囊，以掩盖克拉霉素的苦味。创新地使用Eudragit EPO和Surelease®的水分散液，通过一步喷雾干燥方法将CAM封装成微胶囊。以药物含量和T6%(药物释放时间等于6% w/w)为指标，优化进风温度、气流速率、CAM-聚合物比和CAM粒径。采用扫描电镜(SEM)、红外光谱(FT-IR)和PXRD对粉末的粒径和微观结构进行了表征。此外，还对所选批次进行了药物含量、包封效率、体外释放度、苦味和稳定性研究。EPO-Surelease®(1:4)微胶囊的平均直径(D50)为37.69±3.61 μm，直径跨度为2.395。EPO-Surelease®(1:4)的药含量和包封率分别为10.89%和63.7%。EPO-Surelease®(1:4)微胶囊采用水性聚合物分散体喷雾干燥制备，可有效掩盖CAM的苦味。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of microencapsulation 工程技术-工程：化工

CiteScore

6.30

自引率

2.60%

发文量

审稿时长

3 months

期刊介绍： The Journal of Microencapsulation is a well-established, peer-reviewed journal dedicated to the publication of original research findings related to the preparation, properties and uses of individually encapsulated novel small particles, as well as significant improvements to tried-and-tested techniques relevant to micro and nano particles and their use in a wide variety of industrial, engineering, pharmaceutical, biotechnology and research applications. Its scope extends beyond conventional microcapsules to all other small particulate systems such as self assembling structures that involve preparative manipulation. The journal covers: Chemistry of encapsulation materials Physics of release through the capsule wall and/or desorption from carrier Techniques of preparation, content and storage Many uses to which microcapsules are put.