Efficacy and risk of mRNA vaccination in patients with autoimmune inflammatory rheumatic diseases.

IF 5 3区 医学 Q2 IMMUNOLOGY
Yasuhiro Kato, Takayoshi Morita, Atsushi Kumanogoh
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引用次数: 2

Abstract

Coronavirus disease 2019 (COVID-19), which spread worldwide from Wuhan, China, in 2019, appeared for a time to be overcome by the remarkable efficacy of mRNA vaccines; however, new variants of severe acute respiratory syndrome coronavirus 2 have emerged and remain rampant. The involvement of the virus in the emergence of variant strains and the relationship between vaccine efficacy and immunosuppressive drugs have attracted significant attention, particularly with regard to patients with autoimmune inflammatory rheumatic disease (AIRD) who take immunosuppressive drugs. This review outlines the relationship between mRNA vaccines, one of the key strategies against COVID-19, and AIRD and discusses the immune response elicited by mRNA vaccines. Furthermore, the impact of immunosuppressive agents on the mRNA vaccine-induced immune response in patients with AIRD and side effects of the vaccine, such as exacerbation of the underlying disease, is outlined.

Abstract Image

自身免疫性炎症性风湿病患者接种mRNA疫苗的疗效和风险
2019年从中国武汉传播到世界各地的新型冠状病毒病(COVID-19),曾一度因mRNA疫苗的显著疗效而被克服;然而,严重急性呼吸综合征冠状病毒的新变种已经出现并继续猖獗。病毒参与变异毒株的出现以及疫苗效力与免疫抑制药物之间的关系引起了极大的关注,特别是对于服用免疫抑制药物的自身免疫性炎症性风湿病(AIRD)患者。本文综述了新冠病毒关键策略之一mRNA疫苗与AIRD的关系,并讨论了mRNA疫苗引发的免疫应答。此外,本文还概述了免疫抑制剂对AIRD患者mRNA疫苗诱导的免疫反应的影响,以及疫苗的副作用,如潜在疾病的恶化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
11.10
自引率
1.20%
发文量
45
审稿时长
11 weeks
期刊介绍: Inflammation and Regeneration is the official journal of the Japanese Society of Inflammation and Regeneration (JSIR). This journal provides an open access forum which covers a wide range of scientific topics in the basic and clinical researches on inflammation and regenerative medicine. It also covers investigations of infectious diseases, including COVID-19 and other emerging infectious diseases, which involve the inflammatory responses. Inflammation and Regeneration publishes papers in the following categories: research article, note, rapid communication, case report, review and clinical drug evaluation.
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