Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research.

IF 3 4区 医学 Q2 NEUROSCIENCES
Serena-Kaye Sims, Brynna Wilken-Resman, Crystal J Smith, Ashley Mitchell, Lilly McGonegal, Catrina Sims-Robinson
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引用次数: 15

Abstract

Ischemic stroke and traumatic brain injury (TBI) are among the leading causes of death and disability worldwide with impairments ranging from mild to severe. Many therapies are aimed at improving functional and cognitive recovery by targeting neural repair but have encountered issues involving efficacy and drug delivery. As a result, therapeutic options for patients are sparse. Neurotrophic factors are one of the key mediators of neural plasticity and functional recovery. Neurotrophic factors such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) serve as potential therapeutic options to increase neural repair and recovery as they promote neuroprotection and regeneration. BDNF and NGF have demonstrated the ability to improve functional recovery in preclinical and to a lesser extent clinical studies. Direct and indirect methods to increase levels of neurotrophic factors in animal models have been successful in improving postinjury outcome measures. However, the translation of these studies into clinical trials has been limited. Preclinical experiments have largely failed to result in significant impacts in clinical research. This review will focus on the administration of these neurotrophic factors in preclinical and clinical stroke and TBI and the challenges in translating these therapies from the bench to the clinic.

脑源性神经营养因子和神经生长因子治疗脑损伤:目前临床前和临床研究中的转化挑战。
缺血性中风和创伤性脑损伤(TBI)是世界范围内造成死亡和残疾的主要原因,损伤程度从轻微到严重不等。许多疗法旨在通过靶向神经修复来改善功能和认知恢复,但遇到了涉及疗效和药物递送的问题。因此,患者的治疗选择很少。神经营养因子是神经可塑性和功能恢复的重要介质之一。神经营养因子如脑源性神经营养因子(BDNF)和神经生长因子(NGF)作为潜在的治疗选择,可以促进神经保护和再生,从而增加神经修复和恢复。BDNF和NGF在临床前和临床研究中已经证明了改善功能恢复的能力。在动物模型中,直接和间接增加神经营养因子水平的方法已经成功地改善了损伤后的结果测量。然而,将这些研究转化为临床试验是有限的。临床前实验在很大程度上未能对临床研究产生重大影响。这篇综述将重点关注这些神经营养因子在临床前和临床卒中和TBI中的应用,以及将这些疗法从实验室转化为临床所面临的挑战。
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来源期刊
Neural Plasticity
Neural Plasticity NEUROSCIENCES-
CiteScore
6.80
自引率
0.00%
发文量
77
审稿时长
16 weeks
期刊介绍: Neural Plasticity is an international, interdisciplinary journal dedicated to the publication of articles related to all aspects of neural plasticity, with special emphasis on its functional significance as reflected in behavior and in psychopathology. Neural Plasticity publishes research and review articles from the entire range of relevant disciplines, including basic neuroscience, behavioral neuroscience, cognitive neuroscience, biological psychology, and biological psychiatry.
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