Genetic polymorphism of 27 Y-STR loci in Kazakh populations from Eastern Kazakhstan.

IF 1.2 4区医学 Q2 ANTHROPOLOGY

Annals of Human Biology Pub Date : 2023-02-01 DOI:10.1080/03014460.2023.2170465

Yeldar Ashirbekov, Anastassiya Nogay, Arman Abaildayev, Aigul Zhunussova, Zhaxylyk Sabitov, Maxat Zhabagin

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引用次数: 3

Abstract

Background: The establishment of a national haplotype database is important for forensic and genetic applications and requires studying genetic polymorphisms at Y-STR sites. However, the genetic structure of the Eastern Kazakhstan population is poorly characterised.

Aim: To investigate the genetic polymorphisms of 27 Y-STR loci in the Kazakh population from Eastern Kazakhstan and analyse the population genetic relationships of the Eastern Kazakhs with other populations.

Subjects and methods: The Yfiler Plus kit was utilised to genotype 246 healthy, unrelated males from Eastern Kazakhstan. Based on the raw data, haplotype and allele frequencies along with forensic parameters were calculated, and an MDS plot was constructed.

Results: A total of 207 haplotypes were detected, of which 186 were unique. The haplotype diversity and discrimination capacity were 0.997 and 0.841, respectively. Population comparisons showed that Eastern Kazakhs have close genetic relationships with Kazakhs from Xinjiang, China. At the same time, a difference was found between the studied population and the previous one in the same part of Kazakhstan.

Conclusions: The obtained haplotypes will help to expand the Kazakhstan Y-chromosome reference database and will be useful for future genetic research and forensic applications.

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哈萨克斯坦东部哈萨克人群27个Y-STR基因座的遗传多态性

背景:建立国家单倍型数据库对法医和遗传学应用具有重要意义，需要研究Y-STR位点的遗传多态性。然而，东哈萨克斯坦种群的遗传结构特征不明显。目的:研究哈萨克斯坦东部哈萨克族人群中27个Y-STR基因座的遗传多态性，并分析其与其他人群的群体遗传关系。对象和方法:使用Yfiler Plus试剂盒对246名来自哈萨克斯坦东部的无亲缘关系健康男性进行基因分型。根据原始数据，计算单倍型和等位基因频率以及法医学参数，构建MDS图。结果:共检测到207个单倍型，其中186个为独特单倍型。单倍型多样性和辨别能力分别为0.997和0.841。种群比较表明，东哈萨克族与新疆哈萨克族有密切的亲缘关系。与此同时，研究人群与哈萨克斯坦同一地区的先前人群之间存在差异。结论:获得的单倍型将有助于扩大哈萨克斯坦y染色体参考数据库，为今后的遗传研究和法医学应用奠定基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.