Sedation Is Associated with Higher Polyp and Adenoma Detection Rates during Colonoscopy: A Retrospective Cohort Study.

IF 2 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Gastroenterology Research and Practice Pub Date : 2023-02-18 eCollection Date: 2023-01-01 DOI:10.1155/2023/1172478

Chenghu Xu, Dehua Tang, Ying Xie, Muhan Ni, Min Chen, Yonghua Shen, Xiaotan Dou, Lin Zhou, Guifang Xu, Lei Wang, Ying Lv, Shu Zhang, Xiaoping Zou

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Abstract

Background and aims: Currently sedation is a common practice in colonoscopy to reduce pain of patients and improve the operator satisfaction, whereas its impact on examination quality, especially adenoma detection rate (ADR) is still controversial. Thus, we aimed to investigate the association of sedation with ADR.

Methods: Consecutive patients receiving colonoscopy between January 2017 and January 2020 at the Nanjing Drum Tower Hospital, Nanjing, China, were collected. Univariate and multivariate logistic regression models were performed to investigate the association between sedation and ADR. Subgroup analysis and propensity score matching (PSM) analysis, as sensitivity analysis, were performed to validate the independent effect.

Results: The ADR was significantly higher in cases with sedation (ADR: 36.9% vs. 29.1%, odds ratio [OR]: 1.42, 95% confidence interval [CI]: 1.31-1.55, P < 0.001). Multivariate analysis showed that the sedation was an independent factor associated with ADR (OR: 1.49, 95% CI: 1.35-1.65, P < 0.001). The effect was consistent in subgroup analyses (P > 0.05) and PSM analysis (ADR: 37.6% vs. 29.1%, OR: 1.47, 95% CI: 1.33-1.63, P < 0.001).

Conclusion: Sedation was associated with a higher polyp and ADR s during colonoscopy, which can promote the quality of colonoscopy.

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镇静与结肠镜检查中更高的息肉和腺瘤检出率有关：一项回顾性队列研究

背景和目的：目前，镇静是结肠镜检查的常用方法，可减轻患者疼痛并提高操作者满意度，但镇静对检查质量，尤其是腺瘤检出率（ADR）的影响仍存在争议。因此，我们旨在研究镇静与 ADR 的关系：方法：收集2017年1月至2020年1月期间在中国南京鼓楼医院接受结肠镜检查的连续患者。采用单变量和多变量逻辑回归模型研究镇静与ADR之间的关系。作为敏感性分析，还进行了亚组分析和倾向得分匹配（PSM）分析，以验证其独立效应：结果：使用镇静剂的病例的 ADR 明显更高（ADR：36.9% 对 29.1%，几率比 [OR]：1.42，95% 置信区间）：1.42，95% 置信区间 [CI]：1.31-1.55, P < 0.001).多变量分析显示，镇静是与 ADR 相关的独立因素（OR：1.49，95% 置信区间：1.35-1.65，P <0.001）。该效应在亚组分析（P > 0.05）和 PSM 分析（ADR：37.6% vs. 29.1%，OR：1.47，95% CI：1.33-1.63，P < 0.001）中一致：结论：在结肠镜检查过程中，镇静与较高的息肉和 ADR 相关，这可以提高结肠镜检查的质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastroenterology Research and Practice GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

4.40

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Gastroenterology Research and Practice is a peer-reviewed, Open Access journal which publishes original research articles, review articles and clinical studies based on all areas of gastroenterology, hepatology, pancreas and biliary, and related cancers. The journal welcomes submissions on the physiology, pathophysiology, etiology, diagnosis and therapy of gastrointestinal diseases. The aim of the journal is to provide cutting edge research related to the field of gastroenterology, as well as digestive diseases and disorders. Topics of interest include: Management of pancreatic diseases Third space endoscopy Endoscopic resection Therapeutic endoscopy Therapeutic endosonography.