Utilization of NKX3.1, P501S, Prostate-Specific Antigen, and Steroidogenic Factor 1 to Distinguish Malignant Leydig Cell Tumor From Metastatic Prostatic Adenocarcinoma to the Testis.

IF 3.7 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY
Eric Erak, Thomas M Ulbright, Jonathan Epstein
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引用次数: 0

Abstract

Context.—: A recent study demonstrated that NKX3.1-positive staining can uncommonly be seen in testicular Sertoli cell tumors (1 of 4 cases). Also, it was reported that 2 of 3 Leydig cell tumors of the testis showed diffuse cytoplasmic staining for P501S, although it was unclear whether it was specific granular staining that defines true positivity. However, Sertoli cell tumors do not typically pose a diagnostic dilemma with metastatic prostate carcinoma to the testis. In contrast, malignant Leydig cell tumors, which are exceedingly rare, can closely resemble Gleason score 5 + 5 = 10 prostatic adenocarcinoma metastatic to the testis.

Objective.—: To evaluate the expression of prostate markers in malignant Leydig cell tumors and steroidogenic factor 1 (SF-1) in high-grade prostate adenocarcinoma, as no data are currently published on these topics.

Design.—: Fifteen cases of malignant Leydig cell tumor were collected from 2 large genitourinary pathology consult services in the United States from 1991 to 2019.

Results.—: All 15 cases were negative immunohistochemically for NKX3.1, and all 9 with available additional material were negative for prostate-specific antigen and P501S and positive for SF-1. SF-1 was negative immunohistochemically in a tissue microarray with cases of high-grade prostatic adenocarcinoma.

Conclusions.—: The diagnosis of malignant Leydig cell tumor and its distinction from metastatic adenocarcinoma to the testis can be made immunohistochemically on the basis of SF-1 positivity and negativity for NKX3.1.

应用NKX3.1、P501S、前列腺特异性抗原和甾体生成因子1鉴别睾丸转移性前列腺腺癌与恶性间质细胞瘤
上下文。最近的一项研究表明,nkx3.1阳性染色在睾丸支持细胞肿瘤中罕见(4例中有1例)。此外,据报道,睾丸3个间质细胞瘤中有2个显示P501S的弥漫细胞质染色,但尚不清楚是否为定义真阳性的特异性颗粒染色。然而,支持细胞瘤通常不会与睾丸转移性前列腺癌形成诊断困境。恶性间质细胞瘤极为罕见,与Gleason评分5 + 5 = 10的睾丸转移前列腺腺癌非常相似。目的:评估恶性间质细胞肿瘤中前列腺标志物的表达和高级别前列腺腺癌中类固醇生成因子1 (SF-1)的表达,目前尚无相关数据发表。-:收集1991 - 2019年美国2家大型泌尿生殖系统病理咨询机构的恶性间质细胞瘤15例。-: 15例患者NKX3.1免疫组化检测均为阴性,9例患者可获得的补充材料均为前列腺特异性抗原和P501S阴性,SF-1阳性。高级别前列腺癌患者的组织芯片免疫组化结果显示SF-1呈阴性。-:根据NKX3.1的SF-1阳性和阴性,可通过免疫组织化学方法诊断睾丸恶性间质细胞瘤并与睾丸转移性腺癌区分。
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来源期刊
CiteScore
9.20
自引率
2.20%
发文量
369
审稿时长
3-8 weeks
期刊介绍: Welcome to the website of the Archives of Pathology & Laboratory Medicine (APLM). This monthly, peer-reviewed journal of the College of American Pathologists offers global reach and highest measured readership among pathology journals. Published since 1926, ARCHIVES was voted in 2009 the only pathology journal among the top 100 most influential journals of the past 100 years by the BioMedical and Life Sciences Division of the Special Libraries Association. Online access to the full-text and PDF files of APLM articles is free.
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