Assessment of the Retinal Nerve Fibre Layer, Retina, and Choroid in Osteogenesis Imperfecta.

IF 0.8 4区医学 Q4 OPHTHALMOLOGY

Klinische Monatsblatter fur Augenheilkunde Pub Date : 2024-11-01 Epub Date: 2023-01-12 DOI:10.1055/a-1947-5339

Ali Keles, Mehmet Citirik, Nursel Muratoglu Sahin, Suleyman Korhan Karaman, Semra Cetinkaya

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引用次数: 0

Abstract

Background: Osteogenesis imperfecta (OI) is a genetic disorder in which there are problems in tissues containing type I collagen, predominantly the cornea and sclera in the eye. Although there are many studies on problems with the anterior segment of the eye in patients with OI, studies on posterior structures are limited. Involvement of the sclera may affect the retinal nerve fibre layer (RNFL), which is indirectly related to intraocular pressure. In addition, the retina and choroid containing type I collagen may be affected. The aim of the study was to compare the posterior segment structures of the eye, including the RNFL, retina, and choroid, in patients with OI to those of healthy control subjects.

Methods: This cross-sectional study recruited 19 patients with OI, as well as 22 age- and gender-similar healthy control subjects. Measurements of the RNFL, retina, and choroid were obtained with optical coherence tomography (Spectralis SD-OCT, Heidelberg Engineering, Heidelberg, Germany).

Results: Patients with OI (mean age 14.32 ± 5.08 years) and the control group (mean age 13.73 ± 3.56 years) had similar age, refractive error, and intraocular pressure values (p > 0.05). There was no difference between groups in terms of RNFL thickness, including the superonasal, nasal, inferonasal, inferotemporal, temporal, and superotemporal sectors, retinal thickness, and choroidal thickness from five different locations (p > 0.05, for all).

Conclusion: According to these results, OI does not clinically affect the RNFL, retina, and choroid in childhood.

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评估成骨不全症患者的视网膜神经纤维层、视网膜和脉络膜。

背景：成骨不全症（OI）是一种遗传性疾病，含有 I 型胶原蛋白的组织（主要是眼睛的角膜和巩膜）会出现问题。虽然对 OI 患者眼球前段问题的研究很多，但对眼球后部结构的研究却很有限。巩膜受累可能会影响视网膜神经纤维层（RNFL），这与眼压有间接关系。此外，含有 I 型胶原蛋白的视网膜和脉络膜也可能受到影响。本研究旨在比较 OI 患者与健康对照组的眼球后段结构，包括视网膜神经纤维层、视网膜和脉络膜：这项横断面研究招募了 19 名 OI 患者以及 22 名年龄和性别相似的健康对照组受试者。采用光学相干断层扫描（Spectralis SD-OCT，海德堡工程公司，德国海德堡）测量 RNFL、视网膜和脉络膜：OI患者（平均年龄（14.32 ± 5.08）岁）与对照组（平均年龄（13.73 ± 3.56）岁）的年龄、屈光不正和眼压值相似（P > 0.05）。组间的 RNFL 厚度（包括上颞区、鼻侧、下鼻侧、下颞区、颞侧和上颞区）、视网膜厚度和五个不同位置的脉络膜厚度均无差异（P > 0.05）：根据这些结果，OI 不会对儿童期的 RNFL、视网膜和脉络膜造成临床影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Klinische Monatsblatter fur Augenheilkunde 医学-眼科学

CiteScore

1.30

自引率

0.00%

发文量

235

审稿时长

4-8 weeks

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